Results 81 to 90 of about 374,356 (270)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Low rates of hybridization between European wildcats and domestic cats in a human‐dominated landscape

Ecology and Evolution, 2018
Hybridization between wild species and their domestic congeners is considered a major threat for wildlife conservation. Genetic integrity of the European wildcat, for instance, is a concern as they are outnumbered by domestic cats by several orders of ...
Katharina Steyer, Annika Tiesmeyer, Violeta Muñoz‐Fuentes, Carsten Nowak   +3 more
doaj   +1 more source

Fish genetics research in member countries and institutions of the International Network on Genetics in Aquaculture: Proceedings of the Fifth Steering Committee Meeting of INGA [PDF]

A conference proceedings of the Fifth Steering Committee Meeting of the International Network on Genetics in Aquaculture (INGA), this publication incorporates information drawn from aquaculture genetics research undertaken or in progress in member ...
Acosta, B.O. (eds.), Gupta, M.V.
core  

Are current ecological restoration practices capturing natural levels of genetic diversity? A New Zealand case study using AFLP and ISSR data from mahoe (Melicytus ramiflorus) [PDF]

, 2015
Sourcing plant species of local provenance (eco-sourcing) has become standard practice in plant community restoration projects. Along with established ecological restoration practices, knowledge of genetic variation in existing and restored forest ...
Clarke, Andrew C., Clarkson, Fiona Marie, Gemmill, Chrissen E.C., Goshorn, Mary, Stevens, Mark I.   +4 more
core   +2 more sources

History and structure of the closed pedigreed population of Icelandic Sheepdogs [PDF]

, 2009
Background - Dog breeds lose genetic diversity because of high selection pressure. Breeding policies aim to minimize kinship and therefore maintain genetic diversity.
Pieter A Oliehoek, Piter Bijma, Arie van der Meijden, R Pong-Wong, AK Sonesson, GJ Ubbink, GJ Ubbink, GJ Ubbink, JD Ballou, RK Wayne, AL Nielen, S Bjornerfeldt, GJ Ubbink, EA Ostrander, L Maignel, R Frankham, A Caballero, RC Lacy, RC Lacy, PA Oliehoek, TH Meuwissen, H Eding, PHA Sneath, S Wright, G Leroy, P Oliehoek, I Głażewska, GA Ólafsdóttir   +27 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Optimization of the composition of crop collections for ex situ conservation [PDF]

, 2009
Many crop genetic resources collections have been established without a clearly defined conservation goal or mandate, which has resulted in collections of considerable size, unbalanced composition and high levels of duplication.
Engels, J.M.M., Hintum, T.J.L., van, Hoekstra, R., Treuren, R., van   +3 more
core   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Unraveling the Complexity of the Ne/Nc Ratio for Conservation of Large and Widespread Pelagic Fish Species: Current Status and Challenges

Evolutionary Applications
Estimating and understanding the ratio between effective population size (Ne) and census population size (Nc) are pivotal in the conservation of large marine pelagic fish species, including bony fish such as tunas and cartilaginous fish such as sharks ...
Chrystelle Delord, Sophie Arnaud‐Haond, Agostino Leone, Jonathan Rolland, Natacha Nikolic   +4 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source