Results 91 to 100 of about 45,833 (250)
First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria
Advanced Science, EarlyView.We report the first PROTACs designed to degrade progerin, introducing a novel therapeutic approach for progeria. The best compound, UCM‐18142, significantly reduces progerin levels and improves key disease phenotypes in patient‐derived cells and in the LmnaG609G/G609G mouse model, paving the way for new treatment strategies targeting the root cause of ...
Jon Macicior‐Michelena +5 more
wiley +1 more source
Advanced Science, EarlyView.A neural network‐enabled permittivity engineering paradigm is introduced, transcending traditional trial‐and‐error design. By decoupling electromagnetic parameters and screening a high‐throughput feature space, an ultrathin (1.0 mm) magnetic absorber is inversely designed, experimentally achieving a superior and customizable 5.1 GHz bandwidth and ...
Chenxi Liu +9 more
wiley +1 more source
Two-Field Integrable Evolutionary Systems of the Third Order and Their Differential Substitutions
Symmetry, Integrability and Geometry: Methods and Applications, 2008 A list of forty third-order exactly integrable two-field evolutionary systems is presented. Differential substitutions connecting various systems from the list are found. It is proved that all the systems can be obtained from only two of them.
Maxim Ju. Balakhnev, Anatoly G. Meshkov
doaj +1 more source
Advanced Science, EarlyView.Hydrogen incorporation in palladium is directly probed using in situ ambient‐pressure hard X‐ray photoelectron spectroscopy under realistic, application‐relevant conditions. Correlated structural, spectroscopic, and theoretical analysis reveals how hydrogen loading modifies structure, electronic structure, and metal‐hydrogen bonding, resolving long ...
Lars J. Bannenberg +8 more
wiley +1 more source
Advanced Science, EarlyView.This study demonstrates that in high‐alloy systems, nanoclusters with high solute tolerance can effectively suppress compositional segregation. This mitigation leads to a concurrent 18.7% increase in strength and 41.5% improvement in ductility, which is attributed to a shear‐bypass synergistic strengthening mechanism. The findings provide a new pathway
Wei Yu +10 more
wiley +1 more source
Physics‐Embedded Neural Network: A Novel Approach to Design Polymeric Materials
Advanced Science, EarlyView.Traditional black‐box models for polymer mechanics rely solely on data and lack physical interpretability. This work presents a physics‐embedded neural network (PENN) that integrates constitutive equations into machine learning. The approach ensures reliable stress predictions, provides interpretable parameters, and enables performance‐driven, inverse ...
Siqi Zhan +8 more
wiley +1 more source
Expanding Newton Mechanics with Neutrosophy and Quadstage Method ──New Newton Mechanics Taking Law of Conservation of Energy as Unique Source Law [PDF]
Neutrosophic Sets and Systems, 2014 Neutrosophy is a new branch of philosophy, and "Quad-stage" (Four stages) is the expansion of Hegel’s triad thesis, antithesis, synthesis of development.
Fu Yuhua
doaj
Deformation‐Induced Formation of Stray Grains in Additive Manufacturing of Single Crystals
Advanced Science, EarlyView.Stray grain formation severely limits the additive manufacturing of single‐crystal alloys. By integrating in situ synchrotron techniques, ex situ characterization, and multi‐scale multi‐physics modeling, the authors reveal that stray grains originate from dislocations at the solid‐liquid interface, rather than thermal supercooling in conventional ...
Dongsheng Zhang +11 more
wiley +1 more source
Lie symmetry analysis and conservation laws for the (2+1)-dimensional Mikhalev equation
Electronic Journal of Differential Equations, 2021 Xinyue Li +3 more
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Surface Plasmon Enhanced Photoluminescence of Carbon Dots Formed In Situ on Silver Gratings
Advanced Science, EarlyView.Carbon emitters formed in situ on a silver grating via plasmonic catalysis yield enhanced spontaneous emission by preferential radiative decay into surface plasmons. Enhancement manifests as emission exhibiting characteristics of coherence (polarization, directionality), and accelerated lifetimes of ∼30 ps, yielding Purcell factors of ∼70.
Maryam Sadat Amiri Naeini +5 more
wiley +1 more source