Results 21 to 30 of about 660,054 (306)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

University College London: Library DDA works PPG15 justification. Conservation strategy report. [PDF]

, 2004
Introduction: This report has been prepared for the Estates and Facilities Division of University College London (UCL). UCL needs to make alterations to the Wilkins building to improve access to the library (on its upper floors) by the end of the year
Filmer-Sankey, W., Markham, L.
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Bird species (Charadriiformes) does not impact endosymbiotic bacteria (Gammaproteobacteria) of their ectoparasites (Insecta: Phthiraptera: Ischnocera)

Avian Research
Endosymbiotic bacteria of insects can facilitate host expansion into novel niches by providing their host with a fitness benefit such as vitamins or amino acids that are otherwise lacking in their hosts' diet.
Alexandra A. Grossi, Min Zhang, Fasheng Zou, Daniel R. Gustafsson   +3 more
doaj   +1 more source

Conservation of library collections

IFLA Journal, 2015
Limitations in the field of preservation of library collections have resulted in the destruction of many important documents, including rare books and manuscripts that, until recently, have not been sufficiently addressed. Although scientific approaches to document preservation have been developed, successful application has been met with substantial ...
openaire   +2 more sources

Academic Libraries’ Sustainable Preservation and Conservation Practices

Preservation, Digital Technology & Culture, 2022
Abstract Studies on climate change and sustainability have been gaining interest within the global preservation and conservation communities. However, studies related to sustainability in library preservation and conservation, especially in academic libraries, are still limited.
Yeni Budi Rachman, Wiwit Ratnasari
openaire   +1 more source

Evolutionary conservation of influenza A PB2 sequences reveals potential target sites for small molecule inhibitors. [PDF]

, 2017
The influenza A basic polymerase protein 2 (PB2) functions as part of a heterotrimer to replicate the viral RNA genome. To investigate novel PB2 antiviral target sites, this work identified evolutionary conserved regions across the PB2 protein sequence ...
Kukol, A., Kukol, A., Patel, H., Patel, H.   +3 more
core   +3 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Conservation Documentation in Research Libraries

Library Resources & Technical Services, 2013
Conservation professionals are ethically bound to produce and preserve conservation documentation. The research described in this paper investigates conservation documentation methods and practice in academic research libraries. The author conducted a literature review and developed and implemented a survey to both record current conservation ...
openaire   +2 more sources

East Kingston Buffer Outreach, CTAP Program [PDF]

, 2010
Rockingham Planning Commission worked with the East Kingston Conservation Commission to identify buffer areas on the Pheasant Run conservation property, install buffer boundary markers and interpretive signage for entrances, buffers and wetlands on the ...
LaBranche, Julie
core   +1 more source