Results 31 to 40 of about 660,054 (306)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Patterns and processes underlying understory songbird communities in southern China

Ecology and Evolution
Understory bird communities, especially those comprising insectivores, are highly sensitive to forest loss and fragmentation. Currently, there is little knowledge regarding the large‐scale diversity patterns of understory bird communities, particularly ...
Fangyuan Liu, Xiaoping Yu, Xianli Che, Qiang Zhang, Alexandra Ashley Grossi, Min Zhang, Zhengzhen Wang, Fasheng Zou   +7 more
doaj   +1 more source

In search of Humboldt’s colors: materials and techniques of a 17th-century lacquered gourd from Colombia

Heritage Science, 2020
In 2014 the Hispanic Society Museum & Library, New York, acquired a viceregal Spanish American lacquered gourd, dating to 17th-century Colombia, which was decorated using an indigenous technique known as barniz de Pasto. This technique employs local, raw
Federica Pozzi, Elena Basso, Monica Katz
doaj   +1 more source

Ancestral library identifies conserved reprogrammable liver motif on AAV capsid

Cell Reports Medicine, 2021
Gene therapy is emerging as a modality in 21st-century medicine. Adeno-associated viral (AAV) gene transfer is a leading technology to achieve efficient and durable expression of a therapeutic transgene. However, the structural complexity of the capsid has constrained efforts to engineer the particle toward improved clinical safety and efficacy.
Eric Zinn, Carmen Unzu, Pauline F. Schmit, Heikki T. Turunen, Nerea Zabaleta, Julio Sanmiguel, Allegra Fieldsend, Urja Bhatt, Cheikh Diop, Erin Merkel, Rakesh Gurrala, Bryan Peacker, Christopher Rios, Kathleen Messemer, Jennifer Santos, Reynette Estelien, Eva Andres-Mateos, Amy J. Wagers, Christopher Tipper, Luk H. Vandenberghe   +19 more
openaire   +2 more sources

Defending the aesthetic: the conservation of an artist’s book [PDF]

, 2013
Modern and contemporary books, easily replaceable in the internet age, are weeded from collections and disposed of because of their poor quality materials and construction.
Foden-Lenahan, Erica, Grandal Montero, Gustavo, Hirata Tanaka, Ana Paula   +2 more
core  

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Chemical Conservation of Paper-Based Cultural Heritage

Molecules
Paper-based cultural heritages, represented by ancient books, archives, calligraphy, and paintings, recorded the development of human civilization [...]
Yueer Yan, Yi Tang, Yuliang Yang
doaj   +1 more source

National Library (Republic of Mauritius) : Strategic Plan [PDF]

, 2008
The National Library of the Republic of Mauritius was established as a body corporate under the National Library Act 1996 No. 32. The main role of the National Library of Mauritius is to build the most comprehensive collection of our national heritage by

core  

Open source Matrix Product States: Opening ways to simulate entangled many-body quantum systems in one dimension

, 2017
Numerical simulations are a powerful tool to study quantum systems beyond exactly solvable systems lacking an analytic expression. For one-dimensional entangled quantum systems, tensor network methods, amongst them Matrix Product States (MPSs), have ...
Carr, Lincoln D., Jaschke, Daniel, Wall, Michael L.   +2 more
core   +1 more source