Results 111 to 120 of about 1,057,758 (327)

Gut Microbiota‐Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol‐Induced Cognitive and Social Dysfunction via CB1R‐DRD2‐RAP1 Signaling Axis

open access: yesAdvanced Science, EarlyView.
This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang   +9 more
wiley   +1 more source

Heterotrophy Confers Corals with Resistance but Limits Their Range Expansion: A Case of Marginal Coral Communities

open access: yesEcosystem Health and Sustainability
Climate change may threaten the survival of corals due to ocean warming and increased occurrence of extreme weather events. Yet, marginal coral communities demonstrate remarkable adaptability, largely due to stress-tolerant species.
Qifang Wang   +7 more
doaj   +1 more source

Trading spaces [PDF]

open access: yes
Conservation of natural ...
Betty Joyce Nash
core  

Conservation Value [PDF]

open access: yes, 2010
This paper outlines the significance of the concept of conservation value and discusses ways in which it is determined paying attention to views stemming from utilitarian ethics and from deontological ethics.
Tisdell, Clem
core  

Regulating Tumor Metabolic Reprogramming with Biomimetic Co‐Delivery of Simvastatin and Kynureninase for Immunotherapy

open access: yesAdvanced Science, EarlyView.
After the intravenous injection of biomimetic and pH/ROS‐responsive PTSK@CRM, the nanoparticles can be accumulated in tumors and release Sim and KYNase to inhibit the tumor growth, regulate the metabolism of cholesterol and Kyn, and reverse the immunosuppressive tumor microenvironment.
Jiaxin Yin   +6 more
wiley   +1 more source

Social networks and transformative behaviours in a grassland social‐ecological system

open access: yesPeople and Nature
Social connections among individuals are essential components of social‐ecological systems (SESs), enabling people to take actions to more effectively adapt or transform in response to widespread social‐ecological change.
Holly K. Nesbitt   +12 more
doaj   +1 more source

Cache County, Utah Resource Assessment [PDF]

open access: yes, 2005
This resource assessment is designed to gather and display information specific to Cache County, Utah. This report will highlight the natural and social resources present in the county, detail specific concerns, and be used to aid in resource planning ...
Natural Resources Conservation Service   +2 more
core   +1 more source

Metformin Impairs Breast Cancer Growth through the Inhibition of PRMT6

open access: yesAdvanced Science, EarlyView.
Metformin has a biological activity against breast cancer. However, it is largely unknown about its precise therapeutic targets. Here, histone arginine methyltransferase PRMT6 is identified as a new anti‐cancer target for metformin. Metformin directly binds PRMT6 and inhibits its ability to catalyze histone H3R2 asymmetric dimethylation (H3R2me2a ...
Yinsheng Wu   +9 more
wiley   +1 more source

Influence of salinity, nitrogen and phosphorus concentrations on the physiological and biochemical characteristics of two Chlorophyceae isolated from Fez freshwater, Morocco

open access: yesScientific Reports
Microalgae are widely exploited for numerous biotechnology applications, including biofuels. In this context, Chlamydomonas debaryana and Chlorococcum sp. were isolated from Fez freshwater (Morocco), and their growth and lipid and carbohydrate production
Bouchra Assobhi   +5 more
doaj   +1 more source

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