Results 211 to 220 of about 1,068,650 (333)

Will the Establishment of a National Park Protect More Suitable Habitats for the Qinling Golden Snub-Nosed Monkey? [PDF]

open access: yesEcol Evol
Wu T   +14 more
europepmc   +1 more source

Rethinking Matrigel: The Complex Journey to Matrix Alternatives in Organoid Culture

open access: yesAdvanced Science, EarlyView.
Matrigel remains the most widely used scaffold in organoid and 3D culture despite its murine origin, variability, and translational limitations. This review discusses the barriers to replacing Matrigel with xeno‐free alternatives and introduces practical tools, including a matrix selection checklist and scaffold assessment criteria, to guide the ...
Lisa Wolff, Sven Hendrix
wiley   +1 more source

B‐EPIC: A Transformer‐Based Language Model for Decoding B Cell Immunodominance Patterns

open access: yesAdvanced Science, EarlyView.
B‐Epic: Achieving high‐accuracy B cell epitope prediction through Transformer architecture. Comprehensive validation demonstrates B‐Epic's robust performance across diverse datasets. B‐Epic facilitates vaccine development for H. pylori and EBV, addressing critical public health challenges.
Jun‐Ze Liang   +16 more
wiley   +1 more source

Polysaccharide Adjuvants as Innate Immune Trainers: Bridging Pattern Recognition Receptor (PRR) Activation and Metabolic Reprogramming for Synthetic Vaccine Design

open access: yesAdvanced Science, EarlyView.
Polysaccharides modulate immune responses by engaging pattern recognition receptors (PRRs) to induce T‐cell activation. In vaccine design, their particle size critically influences lymph node targeting and activation mechanisms. By engineering structural complexity and multivalent PRR engagement, polysaccharides enable precise modulation of immune ...
Jeong Hyun Moon   +8 more
wiley   +1 more source

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