Results 211 to 220 of about 168,519,929 (271)

Low SLC8A1 in Colorectal Cancer Dictates Radiotherapy Resistance Through Calcium‐Dependent ANXA2+sEVs Driving M2 Polarization of TAMs

Advanced Science, EarlyView.
SLC8A1 deficiency in colorectal cancer cells increases intracellular calcium signaling, promoting the secretion of ANXA2‐enriched small extracellular vesicles. These vesicles reprogram tumor‐associated macrophages towards an M2 phenotype, which in turn fosters a tumor microenvironment conducive to radioresistance and is associated with poor patient ...
Yimin Fang, Jinghan Zhu, Qian Xiao, Qichun Wei, Xiujing He, Ping Li, Kai Jiang, Yue Liu, Yeting Hu, Weiwei Yu, Chuansheng Guo, Sheng Chen, Jian Zhao, Siqi Dai, Jingsun Wei, Hang Yang, Tongtong Bu, Kefeng Ding, Haiyan Chen   +18 more
wiley   +1 more source

Plant diversity modifies multi-trophic interactions in croplands, grasslands and forests. [PDF]

Sci Adv
Wan NF, Li M, Shen S, Zhou JX, Zhu YT, Woodcock BA, Hu YQ, Nakagawa S, Tilman D, Hector A, Loreau M, Reich PB, Dainese M, Isbell F, Schmid B, Wyckhuys KAG, Gurr GM, Wan L, Eisenhauer N, Hautier Y, Eskelinen A, Bardgett RD, Kardol P, Fraser LH, Su Q, Qiu S, Aartsma Y, Albajes R, Albrecht M, Ali MP, Alvarez HA, Anagonou C, Axmacher JC, Bahauddin D, Bai Y, Bakker ES, Batáry P, Bianchi FJJA, Boetzl FA, Brandmeier J, Bruelheide H, Butcher BA, Butt A, Cai Z, Campbell AJ, Cao F, Cesarz S, Chamorro-Lorenzo L, Chen F, Chen JT, Chen J, Chen LL, Chen Y, Clemente-Orta G, Croijmans L, Crowder D, da Silva Pachú JK, Dassou A, de Sousa Ramalho F, Döring TF, Ebeling A, Fernandes FS, Geisen S, Gidey T, Godoy WAC, Guo J, Hatt S, Heimpel G, Heinze J, Helzer C, Horgan FG, Hu X, Huang Z, Jacobsen SK, Jactel H, Joern A, Jonsson M, Kiriga AW, Kosmala M, Kuang L, Kumar S, Heidari Latiberi M, Li C, Li FR, Li FY, Li J, Li L, Li Q, Li X, Li Y, Li Y, Liu JL, Liu J, Liu WJ, Liu Y, Liu Z, Losapio G, Lu X, Lundin O, Ma Q, Madeira F, Malaquias JB, Ghafouri Moghaddam M, Monmany-Garzia AC, Moreira X, Morente M, Mutua BK, Mutyambai DM, Nakano Y, Novotny V, Ochieng LO, Pappagallo S, Paredes D, Petermann JS, Poelman EH, Portal O, Qu MJ, Ramos Y, Rizvi S, Ruano F, Sang W, Sans-Serra FX, Sattler C, Schöb C, Schrader J, Schuldt A, Settele J, Shang J, Sigsgaard L, Sosa-Gómez DR, Staab M, Steffan-Dewenter I, Stevenson PC, Straub C, Sujii ER, Sutter L, Szefer P, Tahir HM, Tan X, Tanada A, Togni PHB, Török E, Tous-Fandos A, Tovignan S, Tschumi M, Twerski A, Utsumi S, van Apeldoorn DF, Vogel C, Wäckers FL, Wang D, Wang L, Wang L, Wang MQ, Wang S, Wang X, Wang X, Wang Y, Wang YZ, Weisser WW, Welti EAR, Wenda-Piesik A, Wu W, Xi X, Xu Q, Xu Z, Yi H, Zhang L, Zhang X, Zhang X, Zhang Z, Zhong Z, Zhu CD, Zhu H, Zhu P, Zhu Y, Zou Y, Scherber C.   +177 more
europepmc   +1 more source

A Synthetic Platform for Antibody Junctional Diversification Beyond Natural Constraints

Advanced Science, EarlyView.
ARESEC is a synthetic platform that reconstructs functional V(D)J recombination in HEK293T cells. By introducing RSS elements and co‐expressing RAG1/2 and TdT across all three antibody CDRs, it enables programmable junctional diversification and direct generation of high‐affinity variants targeting PD‐1/PD‐L1, overcoming the evolutionary constraints of
Wang Liu, Jun Yang, Yuhang Zhang, Xiaoli Xue   +3 more
wiley   +1 more source

Socioeconomic determinants of livestock depredation by carnivores in the Omo Valley, Southern Ethiopia. [PDF]

BMC Ecol Evol
Maru AW, Asfaw T, Yirga G, Kidane D, Bauer H.   +4 more
europepmc   +1 more source

Atmospheric Water Harvesting Through Polymer Hydrogel Sorbents: Materials Chemistry, Design Strategies, and Applications

Advanced Science, EarlyView.
Polymer‐based hydrogels have emerged as promising materials for atmospheric water harvesting (AWH) due to their high water affinity, tunable network structure, and excellent moisture adsorption‐desorption performance. Functional hydrogel systems enable efficient water capture and controlled release under low‐energy conditions, offering a sustainable ...
Swagata Datta, Sushmit Sen, Nilanjan Dey, Amrita Chatterjee, Ananya Sadhu, Sudipta Sarkar, Pradip K. Maji   +6 more
wiley   +1 more source

From environmental DNA into actionable biodiversity data: Towards the implementation of the Kunming-Montreal Global Biodiversity Framework. [PDF]

J Hered
Lopez MLD, Acharya-Patel N, Allison MJ, Migneault A, Trilesky S, Helbing CC.   +5 more
europepmc   +1 more source

Autophagy Orchestrates Anti‐Tumor Immunity to Enhance Chemosensitivity via the FBXW2/C/EBPβ/TIMP‐2 Axis in Colorectal Cancer

Advanced Science, EarlyView.
Chemotherapy leverages tumor‐cell autophagy to reshape the colorectal cancer immune microenvironment. Autophagy degrades FBXW2 to promote C/EBPβ‐mediated TIMP‐2 transcription and MMP‐9 suppression, driving intra‐tumoral CD8+ T‐cell infiltration. Targeting MMP‐2/9 or restoring TIMP‐2 overcomes chemo‐resistance in autophagy‐deficient tumors. ABSTRACT The
Bing Cheng, Chaoying Wei, Zhitong Niu, Jinxin Chen, Guojie Long, Yingzhen Weng, Qiufeng Liu, Yue Jiang, Panpan Wang, Ronghua Zhang, Qiang Yu, Xiaojian Wu, Wenyu Wang   +12 more
wiley   +1 more source

Beyond unit-level certification: An operational agenda for biodiversity-positive tropical production landscapes. [PDF]

iScience
Zwerts JA.
europepmc   +1 more source

Targeting the PHB2–ACSL3 Lipid‐Remodeling Axis Overcomes Cisplatin Resistance by Restoring Ferroptosis in Gastric Cancer

Advanced Science, EarlyView.
ABSTRACT Platinum‐based chemotherapy resistance remains a major obstacle in gastric cancer (GC) treatment. Through integrated transcriptomic profiling of cisplatin‐resistant xenografts and pharmacogenomic interrogation of the NCI‐60 dataset, we identified Prohibitin‐2 (PHB2) as a previously unrecognized determinant of chemoresistance.
Liang Xu, Wanying Xiang, Xinyue Wang, Yue Pan, Jing Gao, Jiezhen Yang, Yufei Wang, Zhipu Zhu, Man Tong, Lei Jin, Yan Ye   +10 more
wiley   +1 more source

Trade-Offs and Synergies Among Ecosystem Services Influenced by Forest Type and Their Implications for Spatial Management in the Upper Minjiang River Basin, China. [PDF]

Plants (Basel)
Hong L, Zhang G, Cong N, Bai M, Ren P, Xiao J.   +5 more
europepmc   +1 more source