Results 41 to 50 of about 38,757,474 (249)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Navigating power in conservation

Conservation Science and Practice, 2023
Conservation research and practice are increasingly engaging with people and drawing on social sciences to improve environmental governance. In doing so, conservation engages with power in many ways, often implicitly.
Ross T. Shackleton, Gretchen Walters, Jevgeniy Bluwstein, Houria Djoudi, Livia Fritz, Flore Lafaye de Micheaux, Tristan Loloum, Van Thi Hai Nguyen, Mialy Rann Andriamahefazafy, Samantha S. Sithole, Christian A. Kull   +10 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Challenges in the impact evaluation of behaviour change interventions: The case of sea turtle meat and eggs in São Tomé

People and Nature, 2020
Robust impact evaluations are needed for conservation to learn and grow as a field. Currently we lack a large body of evidence on the effects of behaviour change interventions in social‐ecological systems.
Laura Thomas‐Walters, Sara Vieira, Victor Jiménez, Domingas Monteiro, Betânia Ferreira, Robert J. Smith, Diogo Veríssimo   +6 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Making knowledge and making wilderness: The politics of introducing the social sciences into conservation in the Manu National Park, Perú

Journal of Political Ecology
Conservation interventions have historically been guided by Western ontologies and epistemologies that separate humans from nature. Reflecting this, the natural sciences have been dominant in decision-making related to conservation, while the social ...
Eduardo Salazar Moreira
doaj   +2 more sources

Motivating relational organizing behavior for biodiversity conservation

Conservation Science and Practice, 2023
As biodiversity loss and climate change accelerate, more people worldwide are engaging in conservation behaviors to “do their part.” Yet, individual behavior change alone is insufficient for the large‐scale, rapid change needed to address these crises ...
Megan S. Jones, Rebecca M. Niemiec
doaj   +1 more source