Results 51 to 60 of about 38,757,474 (249)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Enabling quantitative data analysis through e-infrastructures [PDF]

, 2009
This paper discusses how quantitative data analysis in the social sciences can engage with and exploit an e-Infrastructure. We highlight how a number of activities which are central to quantitative data analysis, referred to as ‘data management’, can ...
Sinnott, Richard, Lambert, P.S., Jones, Simon, Maxwell, M., Warner, G., Gayle, V., Tan, K., Lambert, Paul, Tan, K.L.L., Tan, Koon Leai Larry, Bowes, A., Sinnott, Richard O., Bell, D.N.F., Jones, S., Blum, Jesse, Turner, K. J., Turner, K.J., Sinnott, R., Lambert, Paul S., Jones, Simon B., Warner, Guy, Lambert, P, Gayle, Vernon, Jones, S.B., Blum, J., Turner, Kenneth J, Blum, Jesse Michael, Sinnott, R.O., Turner, Ken J.   +28 more
core   +2 more sources

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Korean ‘Housewives’ and ‘Hipsters’ Are Not Driving a New Illicit Plant Trade: Complicating Consumer Motivations Behind an Emergent Wildlife Trade in Dudleya farinosa

Frontiers in Ecology and Evolution, 2020
Illegal trade in wild plants receives less scientific and policy attention than illegal trade in wild animals and animal-derived products. One exception to this generalizable trend is the recent emergence of an illegal trade in the California succulent ...
Jared D. Margulies
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Interactions, Spring 1991

, 1990
Department of Family Social Science. (2018). Interactions, Spring 1991.
Department of Family Social Science
core  

Social capital in the context of volunteer conservation initiatives

, 2022
Conservation volunteering aims to benefit species and ecosystems, but whether positive collective social outcomes exist for conservation group participants is largely unknown. To examine the importance of the collective social benefits from conservation,
Margaret C. Stanley, James C. Russell, Russell, James C, Rosie V. Gerolemou, Stanley, Margaret C, Gerolemou, Rosie V   +5 more
core   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Successes and opportunities for solutions‐oriented conservation research: Lessons learned from avian science

Conservation Science and Practice
Conservation science struggles with an ongoing divide between research and action. Given its history of broad public engagement and multi‐scale management coordination, avian conservation typifies many of the challenges, successes, and opportunities ...
Rachel T. Buxton, Miguel F. Jimenez, Aalia I. Khan, Tori D. Bakley, Lisha L. Berzins, Barbara Frei, Elizabeth A. Gow, Autumn‐Lynn Harrison, Osvel Hinojosa‐Huerta, Andrea R. Norris, Brendon Samuels, Douglas C. Tozer, Eric M. Wood, Theodore J. Zenzal Jr., Paul A. Smith, Catherine Jardine, Mark S. Woodrey, Bradley Wilkinson, Angeles Raymundo, Bryan B. Lenz   +19 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source