Results 51 to 60 of about 56,540 (246)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Locating financial incentives among diverse motivations for long-term private land conservation

Ecology and Society, 2017
A variety of policy instruments are used to promote the conservation of biodiversity on private land. These instruments are often employed in unison to encourage land stewardship beneficial for biodiversity across a broad range of program types, but ...
Matthew J. Selinske, Benjamin Cooke, Nooshin Torabi, Mathew J. Hardy, Andrew T. Knight, Sarah A. Bekessy   +5 more
doaj   +1 more source

Motivating relational organizing behavior for biodiversity conservation

Conservation Science and Practice, 2023
As biodiversity loss and climate change accelerate, more people worldwide are engaging in conservation behaviors to “do their part.” Yet, individual behavior change alone is insufficient for the large‐scale, rapid change needed to address these crises ...
Megan S. Jones, Rebecca M. Niemiec
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Making knowledge and making wilderness: The politics of introducing the social sciences into conservation in the Manu National Park, Perú

Journal of Political Ecology
Conservation interventions have historically been guided by Western ontologies and epistemologies that separate humans from nature. Reflecting this, the natural sciences have been dominant in decision-making related to conservation, while the social ...
Eduardo Salazar Moreira
doaj   +2 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Korean ‘Housewives’ and ‘Hipsters’ Are Not Driving a New Illicit Plant Trade: Complicating Consumer Motivations Behind an Emergent Wildlife Trade in Dudleya farinosa

Frontiers in Ecology and Evolution, 2020
Illegal trade in wild plants receives less scientific and policy attention than illegal trade in wild animals and animal-derived products. One exception to this generalizable trend is the recent emergence of an illegal trade in the California succulent ...
Jared D. Margulies
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Publishing social science research in Conservation Biology to move beyond biology [PDF]

Conservation Biology, 2018
Conservation biology arose as a field of academic science and management practice to intervene in what biologists and related professionals identified and perceived as a biodiversity extinction crisis (Soulé 1985). Although it has earlier foundations (e.g., Biological Conservation began to be published in 1968), the new discipline was consolidated in ...
Teel, Tara L, Anderson, Christopher B, Burgman, Mark A, Cinner, Joshua, Clark, Douglas, Estévez, Rodrigo A, Jones, Julia PG, McClanahan, Tim R, Reed, Mark S, Sandbrook, Chris, St John, Freya AV   +10 more
openaire   +4 more sources