Results 61 to 70 of about 336,840 (304)
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Exotic pet supply is a key, predominantly legal, component of global wildlife trade, but few studies have quantified its diversity or global reach. Here, using information extracted from the public (open) Facebook accounts of two wildlife exporters in ...
Lauren A. Harrington +5 more
doaj +1 more source
A worthy conservation target? Revising the status of the rarest bumblebee of Europe
Against the context of global wildlife declines, targeted mitigation strategies have become critical to preserve what remains of biodiversity. However, the effective development of conservation tools in order to counteract these changes relies on ...
Kimberly Przybyla +19 more
core +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Distribution update, conservation status and color in life of the rare Amazonian snake, Eutrachelophis papilio Zaher and Prudente 2019 (Serpentes: Xenodontini) [PDF]
The rare Amazonian snake Eutrachelophis papilio is known from only five individuals, from four localities, belonging to its type-series, the more recent collected over 10 years ago.
Nathalie CITELI +2 more
doaj +2 more sources
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Of concern yet?: Distribution and conservation status of the bonnet macaque Macacaradiata in Goa, India [PDF]
The bonnet macaque Macaca radiata, endemic to peninsular India, is typically ignored in conservation initiatives as it is considered a common species, ubiquitously present across its distribution.
Sengupta, Asmita, Radhakrishna, Sindhu
core +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Conservation status of New Zealand freshwater invertebrates, 2013
The conservation status of 644 freshwater invertebrate taxa, across five Phyla, 28 Orders and 75 Families, was assessed using the New Zealand Threat Classification System (NZTCS) criteria.
Collier, Kevin J. +6 more
core

