Results 31 to 40 of about 599,283 (248)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Conservative Management of Invasive Cervical Resorption: A Case Report

Journal of Pharmacy and Bioallied Sciences
“Invasive cervical resorption” (ICR) is a disorder that impacts the region of root surface that is present below the level of attachment of epithelium. Clinically, it manifests as a pink stain on the cervical part of the tooth.
Youssef Abdullah Algarni
doaj   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Conservative and innovative dialect areas

Taal en Tongval: Language Variation in the Low Countries, 2014
The present paper focuses on conservative and innovative (transitional) dialect areas and the questions of 1) how such areas can be methodologically visualized and 2) how the outcomes can be interpreted.
Christian Schwarz
doaj   +1 more source

The Influence of Domestic Politics of South Korea on its Relations with North Korea and the United States

JSP: Jurnal Ilmu Sosial dan Ilmu Politik, 2020
This paper aims to conduct research on the influence of domestic South Korean politics on relations with the United States and North Korea. In this case, the theory of dominance of domestic political actors explains where the dominance of a group will ...
Miftah Farid Darussalam
doaj   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Are local climate assemblies politically representative of the macro-public they represent, and does this matter?

Environmental Research Communications
Using the results of a follow-up survey circulated to the participants of the Herefordshire Citizens Climate Assembly (HCCA), I compare their stated political identity with the political makeup of the county of Herefordshire (the macro public from which ...
Rachel Coxcoon
doaj   +1 more source

O altfel de perspectivă: Croce, Gentile, Gramsci. Filosofia italiană la începutul secolului XX (A different perspective: Croce, Gentile, Gramsci. Early ‘900 italian philosophy) [PDF]

Polis: Revista de Stiinte Politice, 2016
The social, economic and political developments at the end of the 19th century and the beginning of the 20th century, have produced an intellectual emulation phenomenon on the political ideas level which were the catalyst of the ideologies strongly ...
Angelo CHIELLI, Ioana Cristea DRĂGULIN
doaj  

Thoracolumbar fractures: Nonsurgical versus surgical treatment

Indian Spine Journal, 2018
The thoracolumbar (TL) region is a common site of injury after high-energy trauma which can result in significant disability. Despite advances, controversies continue to exist regarding the management of the injury and indications for surgery.
Gururaj Sangondimath, Kalidutta Das, Kalyan Varma   +2 more
doaj   +1 more source