Results 61 to 70 of about 2,850,589 (369)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Non-Conservative Diffusion and its Application to Social Network Analysis [PDF]

, 2011
The random walk is fundamental to modeling dynamic processes on networks. Metrics based on the random walk have been used in many applications from image processing to Web page ranking.
Ghosh, Rumi, Lerman, Kristina, Surachawala, Tawan, Teng, Shang-Hua, Voevodski, Konstantin   +4 more
core  

Conservative, special-relativistic smoothed particle hydrodynamics

, 2010
We present and test a new, special-relativistic formulation of Smoothed Particle Hydrodynamics (SPH). Our approach benefits from several improvements with respect to earlier relativistic SPH formulations.
Anile, Anile, Anninos, Balsara, Benz, Celotti, Cha, Chow, Del Zanna, Dolag, Dolezal, Donat, Dubal, Eltgroth, Falle, Fock, Gallant, Gingold, Inutsuka, Kheyfets, Laguna, Liang, Lucy, Mann, Mann, Marquina, Marti, Marti, Marti, Monaghan, Monaghan, Monaghan, Monaghan, Monaghan, Monaghan, Morris, Nelson, Norman, Piran, Press, Read, Rosswog, Rosswog, Rosswog, Rosswog, Siegler, Springel, Stephan Rosswog, Taub, Wen   +49 more
core   +1 more source

Hydroxyapatite and Fluorapatite in Conservative Dentistry and Oral Implantology—A Review

Materials, 2019
Calcium phosphate, due to its similarity to the inorganic fraction of mineralized tissues, has played a key role in many areas of medicine, in particular, regenerative medicine and orthopedics.
Kamil Pajor, L. Pajchel, J. Kolmas
semanticscholar   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Amyotrophic Lateral Sclerosis Prevalence Projection in 2040: A Less Rare Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To project ALS prevalence across multiple countries through 2040, accounting for both population aging and increased survival. Methods Data from the Piemonte and Valle d'Aosta ALS register (PARALS) was used to estimate the trends in incidence and prevalence from 2005 to 2019. Survival trends over this period were also assessed.
Rosario Vasta, Stefano Callegaro, Antonio Canosa, Umberto Manera, Maurizio Grassano, Francesca Palumbo, Sara Cabras, Enrico Matteoni, Francesca Di Pede, Filippo De Mattei, Salvatore Tafaro, Neil M. Thakur, Ryan Grosenick, Fabiola De Marchi, Letizia Mazzini, Cristina Moglia, Andrea Calvo, Kuldip D. Dave, Adriano Chiò   +18 more
wiley   +1 more source

Renal Trauma Management in 8 Cities of Iran [PDF]

Acta Medica Iranica, 2009
This prospective study, conducted in 8 cities of Iran from 1999 to 2000. Out of total 16,573 trauma patients, 106 (0.63%) included in this study had renal injury.
Laal M, Khodadadi F, Zarei M.R
doaj  

Emergence of Thermodynamics from Darwinian Dynamics

, 2007
Darwinian dynamics is manifestly stochastic and nonconservative, but has a profound connection to conservative dynamics in physics. In the present paper the main ideas and logical steps leading to thermodynamics from Darwinian dynamics are discussed in a
Ahmed Ghoniem, George Hatsopoulos, Gian Paolo Beretta, Ping Ao   +3 more
core   +1 more source

Shared Genetic Effects and Antagonistic Pleiotropy Between Multiple Sclerosis and Common Cancers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epidemiologic studies have reported inconsistent altered cancer risk in individuals with multiple sclerosis (MS). Factors such as immune dysregulation, comorbidities, and disease‐modifying therapies may contribute to this variability.
Asli Buyukkurt, Marius Ygonia, Ali Manouchehrinia, Philippe Lefrançois, Ingrid Kockum, Adil Harroud   +5 more
wiley   +1 more source

Survival, growth, and functional traits of tropical wet forest tree seedlings across an experimental soil moisture gradient in Puerto Rico

Ecology and Evolution
Droughts are predicted to become more frequent and intense in many tropical regions, which may cause shifts in plant community composition. Especially in diverse tropical communities, understanding how traits mediate demographic responses to drought can ...
David Matlaga, Roel Lammerant, J. Aaron Hogan, María Uriarte, Celimar Rodriguez‐Valle, Jess K. Zimmerman, Robert Muscarella   +6 more
doaj   +1 more source