Results 121 to 130 of about 18,050 (261)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
A Viable Alternative to Basel III Prudential Capital Rules. CEPS Policy Brief No. 291, May 2013 [PDF]
, 2013 Stefano Micossi argues in this paper that the Basel framework for bank prudential requirements is deeply flawed and that the Basel III revision has failed to correct these flaws, making the system even more complicated, opaque and open to manipulation ...
Micossi, Stefano.
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Relative Density Ratio Optimization for Stable and Statistically Consistent Model Alignment
CoRRAligning language models with human preferences is essential for ensuring their safety and reliability. Although most existing approaches assume specific human preference models such as the Bradley-Terry model, this assumption may fail to accurately capture true human preferences, and consequently, these methods lack statistical consistency, i.e., the ...
Hiroshi Takahashi +6 more
openaire +2 more sources
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Bootstrap Consistency for Empirical Likelihood in Density Ratio Models
29pages ...
Zhuang, Weiwei +2 more
openaire +2 more sources
Exploring consistent ratios in morphometry of the proximal tibia: insights for knee arthroplasty
Surgical and Radiologic AnatomyThe current study, which delves into proximal tibia morphometric parameters in a Greek sample, not only analyzes whether specific linear distance ratios are consistent but also paves the way for a potential novel metric system for knee arthroplasty imaging studies using constant ratios.
Koutserimpas, Christos +5 more
openaire +3 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
PENGARUH STRUKTUR HIERARKI TERHADAP CONSISTENCY RATIO PADA ANALYTIC HIERARCHY PROCESS
, 2019 Pengambilan keputusan penting dilakukan ketika dihadapkan dengan banyak alternatif berdasarkan kriteria-kriteria yang ada. Banyak sekali pengambilan keputusan yang terjadi di dalam dunia industri, salah satunya adalah perancangan sistem reseller yang ...
SOESANTO, GREYVALDI CHRISTY
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THE FINANCIAL INDEPENDENCE RATIO: CONSISTENCY OF ECONOMIC RELATION, CONTENT AND TITLE
, 2020 The matter in the article is about the financial independence ratio that one of significant indicators which expresses financial stability of entity. Author shows various views which there are in practice on title, content and calculating of the ratio ...
Khakimov, B.
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