Results 81 to 90 of about 26,229 (261)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

Horizontal coefficient of consolidation from inward- and outward-flow tests

open access: yes, 2018
Vertical drains are widely used to accelerate the consolidation of soft clay deposits when preloading is used as a ground-improvement technique. Barron's theory is generally used for the design of vertical drains.
Sridhar Gangaputhiran   +2 more
core   +1 more source

Analysis of Nonlinear Consolidation Characteristics of Soil Around Tunnels Considering Self-Gravity Stress

open access: yesShanghai Jiaotong Daxue xuebao
Considering the self-gravity stress of the soil around the tunnel, a two-dimensional nonlinear consolidation control equation for saturated soil was established, and solved using the alternating implicit difference method. The correctness of the solution
HU Anfeng, CHEN Yuchao, XIAO Zhirong, XIE Senlin, GONG Zhaoqi
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Effect of clay mineralogy on coefficient of consolidation

open access: yes, 1998
The coefficient of consolidation (Cv) signifies the rate at which a saturated clay undergoes 1-dimensional consolidation when subjected to an increase in pres- sure. Measured in cm2/s, C~ is a function of hydraulic conductivity, k (crn/s), coefficient of
Allam, Mehter M, Robinson, Retnamony G
core  

Investigation of the coefficient of consolidation of fine-grained soils using combined apparatus

open access: yes, 2021
The scope of this investigation is to compare the coefficient of consolidation (cv) values defined by the Taylor’s Square Root of Time Fitting Method, which is obtained from the conventional oedometer tests, with the cv values calculated by Terzaghi’s ...
BALCI, Mehmet Can   +2 more
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Determination of coefficient of consolidation with rowe cell

open access: yes, 2010
Consolidation is one of the most important aspects in soil engineering. Since deformation is one of the important criteria for design purpose, consolidation test is important. Structures built over soft clay will create large settlement on the clay layer.
Widjaja, Liyenita.
core  

Determination of coefficient of rate of horizontal consolidation of peat soil [PDF]

open access: yes, 2006
Encountered extensively in wetlands, fibrous peat is considered as problematic soil because it exhibits unusual compression behavior. When a mass of fibrous peat soil with both vertical and horizontal drainage boundaries is subjected to a consolidation ...
Gofar, Nurly, Kassim, Khairul Anuar
core  

Home - About - Disclaimer - Privacy