Results 61 to 70 of about 1,335,503 (297)

Large-Strain Nonlinear Consolidation of Sand-Drained Foundations Considering Vacuum Preloading and the Variation in Radial Permeability Coefficient

Buildings, 2023
The vacuum preloading method effectively strengthens soft soil foundations with vertical drainage, which produces a smear effect when laying sand drains.
Zan Xu, Penglu Cui, Wengui Cao, Xingyi Zhang, Jiachao Zhang   +4 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A Hansbo's consolidation solution of sand-drained ground with impeded boundaries under vacuum and surcharge preloading

工程科学学报, 2018
The top and bottom boundaries of sand-drained ground were visualized as impeded boundaries to investigate the effects of the pervious behaviors of the cushion above the top and the substratum below the bottom during the consolidation process of sand ...
HU Ya-yuan
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

ESTIMATION OF RELATIONSHIP BETWEEN COEFFICIENT OF CONSOLIDATION AND LIQUID LIMIT OF MIDDLE AND SOUTH IRAQI SOILS

Journal of Engineering, 2011
In this paper, a relationship between the liquid limit and the coefficient of consolidation of Iraqi soils are studied. The samples of soil used in study are undisturbed silty clay.
Asma Y. Al- Tae′e, Abbas F. Al- Ameri   +1 more
doaj   +1 more source

Research on Test Method of Foundation Bed Coefficient in Nanjing Soft Soil Area

Geofluids, 2021
Relying on the geotechnical engineering survey project of Nanjing Lukou Airport, this research adopts the method of combining in situ and indoor testing to analyze the coefficient of soil foundation under different conditions (flow plastic, plastic, and ...
Min Zhang, Tao Qiu
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Consolidation Solution for Sand-drained Ground with Impeded Boundaries Under Vacuum Preloading

工程科学与技术, 2018
Since the cushion generally exists on the top and a substratum below the bottom of sand-drained ground,impeded boundaries were used to describe its effect on consolidation process of sand-drained ground.Assuming that ground deformation satisfies the ...
Yayuan HU
doaj  

Case history and back-analysis of large-scale embankment construction on peat using vacuum consolidation [PDF]

E3S Web of Conferences
This presentation discusses engineering considerations for designing and constructing large-scale embankments on peat deposits in Hokkaido, northern Japan, using the vacuum consolidation method with Prefabricated Vertical Drains (PVDs).
Takahashi Hideaki, Shiraga Shinichiro, Sakakibara Tsukasa, Kochi Taishi, Nishimura Satoshi   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source