Results 61 to 70 of about 26,229 (261)
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
A new method for the determination of coefficient of consolidation
, 1992 The time factor, T, and the degree of consolidation, U, from Terzaghi's theory of consolidation can be shown to have a bilinear behavior when plotted as log (U/T) versus log T.
Pandian, N. S. +2 more
core +1 more source
Stress-dependent consolidation characteristics of marine clay in the Northern Arabian Gulf
Ain Shams Engineering Journal, 2018 The main objective of this paper is to study the variation of the coefficient of consolidation (Cv) with stress level for the marine clay in the Northern Arabian Gulf.
Tamer Elkateb
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Coefficient of consolidation of sandy clay
, 2014 Consolidation is a major issue of geotechnical engineering due to its implications on ground settlement. Efficacy of remedial measures against excessive consolidation relies on understanding of factors affecting coefficient of consolidation. This project
Kusnadi, Andhi Wijaya Harja
core
An Investigation of Time-Dependent Deformation Characteristics of Soft Dredger Fill
Advances in Civil Engineering, 2020 The creep characteristics of soft clays have been studied for decades. However, the lateral deformation of soils is not allowed during the commonly used one-dimensional consolidation tests, which cannot describe the real deformation features of soils in ...
Wanying Wang +3 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source