Results 51 to 60 of about 26,229 (261)

A One-Dimensional Nonlinear Consolidation Analysis of Double-Layered Soil with Continuous Drainage Boundary

Applied Sciences, 2023
Based on the soil nonlinearity assumptions proposed by Mesri, the one-dimensional nonlinear consolidation of double-layered soil is investigated. To better align with engineering reality, a continuous drainage boundary is introduced, bolstering the ...
Yi Zhang, Yong Yin, Mengfan Zong, Wenbing Wu, Zhongling Zong, Guoxiong Mei   +5 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Predicting consolidation coefficient of soft clay by time-displacement-velocity methods [PDF]

, 2021
The coefficient of consolidation is a parameter, governing the rate at which saturated clay undergoes consolidation when subjected to an increase in pressure. The rate and amount of compression in clay varies with the rate that excess pore water pressure
Le, TM, Khabbaz, H
core  

Approximation of the Time Rate of Consolidation for Hydraulically Placed Fine Coal Refuse Using a Variable Coefficient of Consolidation Method

, 2021
Terzaghi’s consolidation theory assumes strain in soil due to applied overburden pressure is small, and permeability and thus the coefficient of consolidation (Cv) remain constant during consolidation.
Drumm, Eric, Palomino, Angelica, Jedari, Cyrus   +2 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

A Hansbo's consolidation solution of sand-drained ground with impeded boundaries under vacuum and surcharge preloading

工程科学学报, 2018
The top and bottom boundaries of sand-drained ground were visualized as impeded boundaries to investigate the effects of the pervious behaviors of the cushion above the top and the substratum below the bottom during the consolidation process of sand ...
HU Ya-yuan
doaj   +1 more source

Study on the consolidation behavior of horizontal drainage foundation under complex aquifer formation conditions in karst regions

Frontiers in Earth Science, 2023
Introduction: The consolidation behavior of horizontal drainage foundation under complex aquifer conditions in karst areas is a hot topic in the field of geotechnical engineering.Methods: This paper presents a modified piecewise-linear model for plane ...
Yunbo Xu, Jiachao Zhang, Jiachao Zhang, Zhongyu Liu, Penglu Cui   +4 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Consolidation Solution for Sand-drained Ground with Impeded Boundaries Under Vacuum Preloading

工程科学与技术, 2018
Since the cushion generally exists on the top and a substratum below the bottom of sand-drained ground,impeded boundaries were used to describe its effect on consolidation process of sand-drained ground.Assuming that ground deformation satisfies the ...
Yayuan HU
doaj