Results 81 to 90 of about 33,997 (302)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Analyse des erreurs phonétiques des apprenants iraniens du FLE : le cas des groupes consonantiques /bR/ et /kR/

open access: yesCorela
This research focuses on phonetic errors in French, in particular with the production of two clusters /bR/ and/kR/ of French as a foreign language (FFL) by 6 learners at the beginner level (A1).
Mohamad-Hossein Otroshi   +1 more
doaj   +1 more source

Turkish /h/ deletion : evidence for the interplay of speech perception and phonology [PDF]

open access: yes, 2013
It has been hypothesized that sounds which are less perceptible are more likely to be altered than more salient sounds, the rationale being that the loss of information resulting from a change in a sound which is difficult to perceive is not as great as ...
Mielke, Jeff
core  

Cross-linguistic study of vocal pathology: perceptual features of spasmodic dysphonia in French-speaking subjects [PDF]

open access: yes, 2003
Clinical characterisation of Spasmodic Dysphonia of the adductor type (SD) in French speakers by Klap and colleagues (1993) appears to differ from that of SD in English. This perceptual analysis aims to describe the phonetic features of French SD.
BRIN M. F.   +12 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Co-phonology vs. Indexed constraint theory: a case study of Perak dialect partial reduplication [PDF]

open access: yes, 2012
This paper presents co-phonologies and indexed constraint theory developed within Optimality theory (Prince and Smolensky, 1993) to account for partial reduplication in Perak dialect of Malay.
Syed Jaafar, Sharifah Raihan
core  

Loanword adaptation as first-language phonological perception [PDF]

open access: yes, 2009
We show that loanword adaptation can be understood entirely in terms of phonological and phonetic comprehension and production mechanisms in the first language. We provide explicit accounts of several loanword adaptation phenomena (in Korean) in terms of
Boersma, Paul, Hamann, Silke
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Implications of cluster substitution in Egyptian Arabic children: 30–48 months

open access: yesThe Egyptian Journal of Otolaryngology
Background Egyptian cluster substitution has not been targeted in Arabic phonology research. The clusters in the Egyptian language are bi-consonantal and word-final.
Marwa Mahmoud Saleh   +3 more
doaj   +1 more source

Optimality Theoretic Account of Acquisition of Consonant Clusters of English Syllables by Persian EFL Learners [PDF]

open access: yesJournal of English Language Teaching and Learning, 2010
This study accounts for the acquisition of the consonant clusters of English syllable structures both in onset and coda positions by Persian EFL learners.
Ali Akbar Jabbari, Leila Arghavan
doaj  

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