Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Preaspiration in Sienese Italian & Its Interaction with Stress in /VC:/ Sequences [PDF]
This paper reports some initial results from our investigation into effects of stress in /VC:/ sequences in Sienese Italian. Our spontaneous speech data show preaspiration in /VC:/ sequences, not previously reported for any variety of Italian.
Marlien, Isabelle +3 more
core +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Dominant-hand Spiral Indices and Dominant–Non-dominant differences for PD Subjects and Controls.
Dominant-hand Spiral Indices and Dominant–Non-dominant differences for PD Subjects and Controls.
Sarah Boschung (3217086) +9 more
core +1 more source
On the Etymology of Self-Designation of Georgians - “Kartveli”
The etymology of self-designation of Georgians has not been solved definitely, even though a number of articles have been devoted to the etymology of the term. There does not exist a generally shared opinion around the issue.
Shalva Gabeskiria
doaj
Mechanisms of adaptation of Christian anthroponyms in Votic and Ingrian: a comparative study [PDF]
In modern Finnic onomastics, the study of the pathways and mechanisms through which foreign borrowings are adapted in closely related languages has gained particular significance.
Dmitriev A.V.
doaj +1 more source
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Blocking of word-boundary consonant lengthening in Sienese Italian [PDF]
This paper examines an aspect of Raddoppiamento sintattico (RS), the lengthening of word-initial consonants following certain words e.g. tre [mm]ele ‘three apples’ in Italian. Most phonological accounts claim the phenomenon is predictable and obligatory (
Warren, Paul +3 more
core +1 more source
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source

