Results 61 to 70 of about 522 (205)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Characteristics of Initial Consonant Clusters in Children with Hearing Loss

, 2017
This study examined characteristics of initial consonant clusters produced by children with hearing loss. The study had three goals. The first was to examine developmental patterns of consonant cluster production in children with hearing loss.
O'Neill, Madelaine
core  

Is there a place for creativity in onomatopoeia-formation?

Acta Psychologica
The purpose of the paper is to fill existing gaps in research by examining the role of divergent thinking abilities of language users, that is, their creative potential, in the formation of onomatopoeia.
Pavol Kačmár, Lívia Körtvélyessy
doaj   +1 more source

Peculiarities of Alliteration in Kalmyk Folk Songs (Analysis of Records Made at Different Times)

Oriental Studies, 2018
Poetics of folk songs reflects the history and context of the artistic phenomena of the Kalmyk people at different stages of its development. It served the basis and determined the essence of national identity, aesthetic criteria and priorities ...
B. M. Kovaeva
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

THE PRINCIPLE OF SYMMETRY IN W. BLAKE’S POEM THE TYGER AND ITS REPRODUCTION IN UKRAINIAN TRANSLATIONS [PDF]

Alfred Nobel University Journal of Philology
The article is devoted to the analysis of Ukrainian translations of William Blake’s poem The Tyger made by V. Koptilov, V. Keis, and V. Bohuslavska, focusing on the embodiment of the principle of symmetry as an organizing principle of the poem, which ...
Tatyana A. Pakhareva, Olena M. Borovska
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Engineering the Carnival of Violence in the Movie, The First Purge [PDF]

Faṣlnāmah-i Pizhūhish-i Huqūq-i Kiyfarī
Cinematic representation of the concepts of crime and criminal justice and investigation the social control function of power institutions in the context of artistic activities are among the most important issues that are studied in cultural criminology,
Hamidreza Daneshnari, Seyed Hossein Hosseini, Mohammad kKarimi bandar abadi   +2 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source