Results 51 to 60 of about 576,908 (281)
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Computer program for the expression of the kinetic equations of enzyme reactions as functions of the rate constants and the initial concentrations [PDF]
Biochemical Journal, 1990 A versatile computer program with an easy input method has been developed for the construction of the terms in kinetic equations of enzyme reactions. It allows the expression of the time-dependence of the concentrations of all of the species involved as functions of the kinetic parameters.
R, Varón +4 more
openaire +2 more sources
, 2017 Programming by Example (PBE) targets at automatically inferring a computer program for accomplishing a certain task from sample input and output. In this paper, we propose a deep neural networks (DNN) based PBE model called Neural Programming by Example (
Shu, Chengxun, Zhang, Hongyu
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
The Analogue Computer as a Voltage-Controlled Synthesiser [PDF]
, 2019 This paper re-appraises the role of analogue computers within electronic and computer music and provides some pointers to future areas of research. It begins by introducing the idea of analogue computing and placing in the context of sound and music ...
Lazzarini, Victor, Timoney, Joseph
core +1 more source
Setting-up early computer programs: D. H. Lehmer's ENIAC computation [PDF]
, 2010 A complete reconstruction of Lehmer's ENIAC set-up for computing the exponents of p modulo two is given. This program served as an early test program for the ENIAC (1946). The reconstruction illustrates the difficulties of early programmers to find a way
Bullynck, Maarten, De Mol, Liesbeth
core +3 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Linear, integer separable and fuzzy programming problems: a united approach towards automatic reformulation [PDF]
, 1986 For mathematical programming (MP) to have greater impact as a decision tool, MP software systems must offer suitable support in terms of model communication and modelling techniques.
Darby-Dowman, K +3 more
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source