Results 71 to 80 of about 576,908 (281)

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Thermal Properties Model for the New Refrigerant HFO-1234yf

Zhileng xuebao, 2012
Based on Peng-Robinson general state equation, combined with group contribution principle and a polynomial method, the thermal state model of the new LGWP refrigerant HFO-1234yf was established and validated with required accuracy.
Jiang Kun, Liu Ying, Jiang Sha
doaj  

A study of systems implementation languages for the POCCNET system [PDF]

, 1976
The results are presented of a study of systems implementation languages for the Payload Operations Control Center Network (POCCNET). Criteria are developed for evaluating the languages, and fifteen existing languages are evaluated on the basis of these ...
Basili, V. R., Franklin, J. W.
core   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Quantum Speedup for Multiuser Detection With Optimized Parameters in Grover Adaptive Search

IEEE Access
Maximum-likelihood multiuser detection incurs a large computational complexity, and its low-complexity detection scheme suffers from a performance loss, where this tradeoff is inevitable and inherent in a classical computer.
Masaya Norimoto, Taku Mikuriya, Naoki Ishikawa   +2 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

QPCF: higher order languages and quantum circuits

, 2018
qPCF is a paradigmatic quantum programming language that ex- tends PCF with quantum circuits and a quantum co-processor. Quantum circuits are treated as classical data that can be duplicated and manipulated in flexible ways by means of a dependent type ...
Paolini, Luca, Piccolo, Mauro, Zorzi, Margherita   +2 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Fast Scalable Construction of (Minimal Perfect Hash) Functions

, 2016
Recent advances in random linear systems on finite fields have paved the way for the construction of constant-time data structures representing static functions and minimal perfect hash functions using less space with respect to existing techniques.
A Goerdt, AM Frieze, AM Odlyzko, BA LaMacchia, BS Majewski, D Belazzougui, D Belazzougui, D Belazzougui, D Belazzougui, FC Botelho, M Aumüller, M Dietzfelbinger, M Dietzfelbinger, N Fountoulakis   +13 more
core   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source