Results 61 to 70 of about 576,908 (281)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Deciding subset relationship of co-inductively defined set constants [PDF]

open access: yes, 2005
Static analysis of different non-strict functional programming languages makes use of set constants like Top, Inf, and Bot denoting all expressions, all lists without a last Nil as tail, and all non-terminating programs, respectively.
Sabel, David   +2 more
core   +2 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Student Use of a Single Lecture Video in a Flipped Introductory Mechanics Course

open access: yes, 2014
In the Fall of 2013, Georgia Tech offered a 'flipped' calculus-based introductory mechanics class as an alternative to the traditional large-enrollment lecture class.
Aiken, John M.   +6 more
core   +1 more source

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

open access: yesFEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca   +6 more
wiley   +1 more source

Modeling and ultrasonic examination of common carotid artery wall thickness changes

open access: yesArchives of Acoustics, 2014
The paper describes the initial results of numeric analysis of plane-strain of a model of the human common carotid artery. The results of computer modeling were compared with the experimental data obtained by means of ultrasonic measurements of the ...
Zbigniew Trawiński, T. Powałowski
doaj  

Optimal Union-Find in Constraint Handling Rules

open access: yes, 2004
Constraint Handling Rules (CHR) is a committed-choice rule-based language that was originally intended for writing constraint solvers. In this paper we show that it is also possible to write the classic union-find algorithm and variants in CHR.
Handling Rules   +2 more
core   +4 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

A Field Guide to Genetic Programming [PDF]

open access: yes, 2008
xiv, 233 p. : il. ; 23 cm.Libro ElectrónicoA Field Guide to Genetic Programming (ISBN 978-1-4092-0073-4) is an introduction to genetic programming (GP).
Langdon, William B.   +2 more
core  

Set Unification

open access: yes, 2005
The unification problem in algebras capable of describing sets has been tackled, directly or indirectly, by many researchers and it finds important applications in various research areas--e.g., deductive databases, theorem proving, static analysis, rapid
Dovier, Agostino   +2 more
core   +1 more source

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