Results 71 to 80 of about 1,118,392 (326)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Optimal Union-Find in Constraint Handling Rules
, 2004 Constraint Handling Rules (CHR) is a committed-choice rule-based language that was originally intended for writing constraint solvers. In this paper we show that it is also possible to write the classic union-find algorithm and variants in CHR.
Handling Rules +2 more
core +4 more sources
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Modeling and ultrasonic examination of common carotid artery wall thickness changes
Archives of Acoustics, 2014 The paper describes the initial results of numeric analysis of plane-strain of a model of the human common carotid artery. The results of computer modeling were compared with the experimental data obtained by means of ultrasonic measurements of the ...
Zbigniew Trawiński, T. Powałowski
doaj
FEBS Open Bio, EarlyView.Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Here, we introduced an intermittent electrical stimulation protocol mimicking the episodic nature of real‐life exercise in vitro by alternating low‐ and high‐frequency stimulation. In comparison with widely used continuous stimulation, it enhanced the rate of glucose and fatty acid oxidation, but not the myokine release.
Klára Gabrišová +11 more
wiley +1 more source
Thermal Properties Model for the New Refrigerant HFO-1234yf
Zhileng xuebao, 2012 Based on Peng-Robinson general state equation, combined with group contribution principle and a polynomial method, the thermal state model of the new LGWP refrigerant HFO-1234yf was established and validated with required accuracy.
Jiang Kun, Liu Ying, Jiang Sha
doaj
Quantum Speedup for Multiuser Detection With Optimized Parameters in Grover Adaptive Search
IEEE AccessMaximum-likelihood multiuser detection incurs a large computational complexity, and its low-complexity detection scheme suffers from a performance loss, where this tradeoff is inevitable and inherent in a classical computer.
Masaya Norimoto +2 more
doaj +1 more source
Eliminating Network Protocol Vulnerabilities Through Abstraction and Systems Language Design
, 2013 Incorrect implementations of network protocol message specifications affect the stability, security, and cost of network system development. Most implementation defects fall into one of three categories of well defined message constraints.
Casey, C. Jasson +3 more
core +1 more source
FEBS Open Bio, EarlyView.Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti +8 more
wiley +1 more source