Results 71 to 80 of about 14,872,406 (354)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Research of Kalman-FOPID algorithm in numerical control constant current source
Dianzi Jishu Yingyong, 2018 In the field of optical measurement, the light source has higher requirements to the constant current source, and the existing constant current source system has the system noise and measurement noise, which affects the output precision of the current ...
Cao Zhenguan, Yu Junfeng, Li Zhiwei
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Epitonga gratiosa Gnezdilov & Constant 2014, comb. nov.
, 2014 Epitonga gratiosa (Melichar, 1906) comb. nov. Lollius gratiosus Melichar, 1906: 194. Note. The current placement of the species is based on examination of the original description and drawing (MELICHAR 1906).Published as part of Gnezdilov, Vladimir
Gnezdilov, Vladimir M. +1 more
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Nauka ta progres transportu, 2010 The article deals with the description of mathematical model of the system of traction electric power supply with load in the short circuit condition as well as the calculation results of this emergency process.
P. E. Mihalichenko
doaj
, 2013 GENERAL DESCRIPTION: The WLD3343 is an easy-to-use analog circuit for space constrained laser diode applications. The WLD3343 maintains precision laser diode current (constant current mode) or stable photodiode current (constant power mode) regulation ...
Constant Current Or Power Operation +1 more
core
IEEE Access, 2020 Battery lifetime represents a significant concern for the techno-economical operation of several applications based on energy storage. Moreover, the charging method is considered as one of the main critical elements in defining and influencing the ...
Mohammed M. Alhaider +5 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Study of the depolarization current in mineral oils [PDF]
, 2014 Polarization and depolarization current measurement is a non-destructive testing method to study the dielectric properties of insulating materials. Two kinds of mineral oils with different aging time have been measured and compared.
Hao, Miao +9 more
core +1 more source