Results 61 to 70 of about 7,169,794 (272)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

History and Progress of Fractional-Order Element Passive Emulators: A Review [PDF]

Radioengineering, 2020
This paper presents a state-of-the-art survey in the area of fractional-order element passive emulators adopted in circuits and systems. An overview of the different approximations used to estimate the passive element values by means of rational ...
A. Kartci, N. Herencsar, J. T. Machado, L. Brancik   +3 more
doaj  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Thermo-hydro-mechanical-air coupling finite element method and its application to multi-phase problems

Journal of Rock Mechanics and Geotechnical Engineering, 2014
In this paper, a finite element method (FEM)-based multi-phase problem based on a newly proposed thermal elastoplastic constitutive model for saturated/unsaturated geomaterial is discussed. A program of FEM named as SOFT, adopting unified field equations
Feng Zhang, Yonglin Xiong, Sheng Zhang, Bin Ye   +3 more
doaj   +1 more source

A numerical investigation of constant-volume non-Boussinesq density currents [PDF]

, 2010
The time-dependent behaviour of non-Boussinesq high-Reynolds-number density currents of density ρc, released from a lock of height h₀ and length x₀ into a ambient of height H and density ρₐ, is considered. We use two dimensional Navier-Stokes simulations
Ungarish, Marius, Balachandar, Sivaramakrishnan, Bonometti, Thomas   +2 more
core  

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Efficiency of Cycled Batteries Analyzed Through Voltage-Current Phase Differences

IEEE Access
Ageing of rechargeable batteries is routinely characterized in the frequency domain by electrochemical impedance spectroscopy, but the technique requires laboratory measurements to be made on a time scale of days. However, the normal cycling of a battery
Marcus T. Wilson, Christopher J. Dunn, Vance Farrow, Michael J. Cree, Jonathan B. Scott   +4 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Practical design of variable fractional-order capacitors with a single tuning feature using field effect transistors and variable capacitance diodes

Scientific Reports
This paper presents two discrete circuit solutions for realizing passive, electronically adjustable constant-phase elements, specifically half-order capacitors with a –45° phase shift.
Roman Sotner, Chloe Black, Jan Jerabek, Todd Freeborn, Simon Colburn, Marek Svoboda   +5 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source