Results 131 to 140 of about 1,540 (202)

Cyclins and Cyclin‐Dependent Kinases: Structure, Biological Functions, and Innovative Targeting Strategies in Cancer

MedComm, Volume 7, Issue 9, September 2026.
This work synthesizes recent insights into the pathological roles of cyclins and cyclin‐dependent kinases (CDKs) across human cancers, highlights state‐of‐the‐art innovative approaches (especially targeted degradation and redistribution of CDK/cyclin proteins) for cancer therapy, and outlines future directions for CDK/cyclin‐related biomedical research.
Suya Zheng, Zhipeng Shen, Yuanfang Wu, Xingze Huang, Zhongyuan Zhang, Jiangyu Liu, Qichun Wei, Wenhao Chen, Ye Chen, Liang Xu   +9 more
wiley   +1 more source

Nanoscale photonic artificial neuron with biological signal processing. [PDF]

Nat Commun
Sestoft JE, Jensen TK, Flodgren V, Das A, Schlosser RD, Alcer D, Lamers M, Kanne T, Borgström MT, Nygård J, Mikkelsen A.   +10 more
europepmc   +1 more source

Neoadjuvant PD‐1 Blockade Tislelizumab (BGB‐A317) in Combination With Etoposide and Platinum‐Based Chemotherapy for Limited‐Disease Small Cell Lung Cancer

MedComm, Volume 7, Issue 9, September 2026.
This study assessed neoadjuvant PD‐1 blockade plus chemotherapy in patients with resectable limited‐stage small cell lung cancer. Peri‐treatment biopsy and surgical samples were analyzed using bulk RNA sequencing and bioinformatics approaches.
Shiyue Wan, Shiqi Hu, Yilv Yan, Fenghuan Sun, Dongliang Bian, Jie Luo, Dong Xie, Wenxin He, Liang Duan, Yuming Zhu, Nan Song, Ming Liu, Hongcheng Liu, Gening Jiang, Peng Zhang   +14 more
wiley   +1 more source

Nematic and chiral superconductivity emerging within the loop-current phase in kagome metals. [PDF]

Nat Commun
Tazai R, Yamakawa Y, Kontani H.
europepmc   +1 more source

Overshooting of Hypoplastic Models With Intergranular Strain: Manifestation, Implications and Remedy

International Journal for Numerical and Analytical Methods in Geomechanics, Volume 50, Issue 13, Page 5068-5091, September 2026.
ABSTRACT Intergranular strain extensions of hypoplasticity (IGS, ISA, GIS) are widely used to model small‐strain and cyclic soil behaviour. However, recent studies and our own simulations reveal that these models can exhibit stress overshooting not only under repeated small loading cycles but also during monotonic loading.
Jan Machaček, Merita Tafili, Carlos Grandas Tavera   +2 more
wiley   +1 more source

Decentralized optimization for effective coordination of transmission and distribution systems with dynamic DER aggregation. [PDF]

Sci Rep
Raghunathan N, Wang Z, Chen F, Yan B.
europepmc   +1 more source

AI‐Revealed Transition From Density‐ to Connectivity‐Controlled Mechanics in Hierarchical Porous Materials

Small, Volume 22, Issue 51, 11 September 2026.
Using synchrotron‐based multiscale imaging, generative modeling algorithms, and computational mechanics models, our study reveals a scale‐dependent transition in bone mechanics. The results of the power‐scaling law illustrate a transition from density‐controlled stiffness at the trabecular scale to connectivity‐controlled, porosity‐sensitive mechanics ...
Milad Masrouri, Federica Buccino, Laura Maria Vergani, Zhao Qin   +3 more
wiley   +1 more source

A differential equation-driven update strategy for density-based topology optimization: implementation with MATLAB codes. [PDF]

Eng Comput
Liu Y, Tan W.
europepmc   +1 more source

Dynamic Characteristics Analysis of a Large Wind Turbine Gearbox Supported by Journal Bearings Under Different Lubrication States

Wind Energy, Volume 29, Issue 9, September 2026.
ABSTRACT Due to their superior load density, planetary gear journal bearings (PGJB) are progressively replacing rolling element bearings in wind turbine gearboxes; therefore, accurately revealing the dynamic characteristics of drivetrains supported by these bearings under variable operating conditions is crucial for ensuring operational reliability ...
Pengcheng Jin, Hong Jiang, Jianxing Zhou, Yuliang Yang   +3 more
wiley   +1 more source

Optimal selection of a metro tunnel excavation method using AHP and TOPSIS: a case study of Tehran metro. [PDF]

Sci Rep
Rostami A, Chakeri H, Shahriar K, Mousapour H.   +3 more
europepmc   +1 more source