Results 101 to 110 of about 654,561 (303)
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
Simulation-based stress testing of banks’ regulatory capital adequacy [PDF]
Banks’ holding of reasonable capital buffers in excess of minimum requirements could alleviate the procyclicality problem potentially exacerbated by the rating-sensitive capital charges of Basel II.
Peura, Samu, Jokivuolle, Esa
core +2 more sources
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
, 2011 Unsteady flow of a thin film of a Newtonian fluid or a non-Newtonian power-law fluid with power-law index N driven by a constant shear stress applied at the free surface, on a plane inclined at an angle α to the horizontal, is considered.
Wilson, Stephen +5 more
core +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
, 2007 A means to predict remaining strength and life of composite components in harsh environments and under complex time-varying loadings can help to optimize designs and cut costs.
Prediction Of Stress-Rupture
core
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
Deformation strength characteristics of unsaturated remoulded loess simulated by BBM model
Yantu gongcheng xuebaoThe BBM model for unsaturated soils is analyzed, studied and validated. A modification is further made to the BBM model, so that the model is more consistent with the variation of matric suction in unsaturated loess.
ZHENG Fang 1, 2, SHAO Shengjun 3, 4
doaj +1 more source
Numerical modelling of lateral stress on integral abutments due to cyclic loading
, 2009 The integral bridge concept eliminates problems associated with expansion joints and bearings used on conventional bridges. However, integral structures are not free from problems, and of particular concern is the magnitude of lateral soil stress which ...
Banks, J.R, Banks, James R
core
, 2012 We performed high-strain torsion experiments on aggregates of Fo 50 olivine to test the influence of imposed boundary conditions on localizing deformation.
Hansen, LN +3 more
core +1 more source