Results 61 to 70 of about 654,561 (303)

Pore pressures and strains after repeated loading of saturated clay [PDF]

open access: yes, 1974
Repeated and sustained loading tests on undrained samples of normally consolidated lacustrine clay are used to prove the existence of a relationship between pore water pressures and axial strains.The behavior of the clay is studied by investigating the ...
Greenwood, JR   +3 more
core   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Is the Zero-Point Energy Real? [PDF]

open access: yes, 2002
I consider the arguments to show that the vacuum energy density should receive a large contribution from the zero-point energy. This is the cosmological constant problem, as it was originally framed. I suggest that the matter is interpretation-dependent,
Simon Saunders, Saunders, Simon
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Adhesive strength of butt joint having constant interface stress distribution without singular stress field

open access: yesNihon Kikai Gakkai ronbunshu
Various testing methods for adhesive strength are prescribed in JIS but no testing method is indicated under no singular stress field. Usually, strength of materials should be considered for plane specimens where uniform stress distributions can be ...
Kazuhiro ODA   +2 more
doaj   +1 more source

Shakedown analysis of a composite cylinder with a cross-hole

open access: yes, 2011
In this study, both the lower and upper bound shakedown limits of a closed-end composite cylinder with or without a cross-hole subject to constant internal pressure and a cyclic thermal gradient are calculated by the Linear Matching Method (LMM ...
Ure, James Michael   +7 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Functional fatigue of NiTi Shape Memory wires for a range of end loadings and constraints [PDF]

open access: yesFracture and Structural Integrity, 2013
The availability of engineering strength data on shape memory alloys (SMAs) under cyclic thermal activation (functional fatigue) is central to the rational design of smart actuators based on these materials. Test results on SMAs under functional fatigue
G. Scirè Mammano, E. Dragoni
doaj  

Novel Accelerating Life Test Method and Its Application by Combining Constant Stress and Progressive Stress

open access: yesChinese Journal of Mechanical Engineering, 2018
Constant stress accelerated life tests (ALTs) can be applied to obtain a high estimation accuracy of reliability measurements, but these are time-consuming tests. Progressive stress ALTs can yield failures more quickly but cannot guarantee the estimation
Wen-Hua Chen   +4 more
doaj   +1 more source

Ratchet limits for a crack in a welded pipe subjected to a cyclic temperature load an a constant mechanical load

open access: yes, 2011
This paper presents the ratchet limit analysis of a pipe with a symmetric crack in a mismatched weld by using the extended Linear Matching Method (LMM). Two loading conditions are considered: i) a cyclic temperature load and a constant internal pressure;
Ure, James Michael   +3 more
core  

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