Results 51 to 60 of about 122,080 (304)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Remapping the Constellation of Walter Benjamin’s Allegorical Method
American, British and Canadian Studies Journal, 2015 The now-longstanding academic revival of allegory, as well as its import as a perennial buzzword of contemporary art criticism, owes much to a group of essays published in the journal October in the early 1980s.
Wong Jack
doaj +1 more source
Global earth mineral inventory: A data legacy
Geoscience Data Journal, 2021 Minerals contain important clues to understanding the complex geologic history of Earth and other planetary bodies. Therefore, geologists have been collecting mineral samples and compiling data about these samples for centuries. These data have been used
Anirudh Prabhu +14 more
doaj +1 more source
Remote Sensing, 2021 With the ability to capture daily imagery of Earth at very high spatial resolutions, commercial smallsats are emerging as a key resource for the remote sensing community.
Amy E. Frazier, Benjamin L. Hemingway
doaj +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
IEEE Journal of Selected Topics in Applied Earth Observations and Remote SensingForests are the largest carbon storage and carbon sinks on land and are closely related to global climate change. Using remote sensing images to monitor global deforestation has become the mainstream method, mainly because of their long time-series ...
Zhipan Wang +6 more
doaj +1 more source
Feminizing world power: A new constellation of women in politics? [PDF]
, 2016 This article charts the emergence of women leaders currently in power, the highest it has ever been with 22 female heads of state and political leaders in 2015.
Peters, Michael A.
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source