Results 71 to 80 of about 147,245 (289)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Loss of epitranscriptomic control of selenocysteine utilization engages senescence and mitochondrial reprogramming☆

Redox Biology, 2020
Critically important to the maintenance of the glutathione (GSH) redox cycle are the activities of many selenocysteine-containing GSH metabolizing enzymes whose translation is controlled by the epitranscriptomic writer alkylation repair homolog 8 (ALKBH8)
May Y. Lee, Andrea Leonardi, Thomas J. Begley, J. Andrés Melendez   +3 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Terra Constellation Exit (Part 2) [PDF]

, 2015
The Terra Constellation Exit power point presentation will discuss the baseline and proposed constellation exit plan and debris ...
Mantziaras, Dimitrios
core  

The Needle in the Haystack: Uncovering the First Whale Shark (Rhincodon typus) Aggregation in the Coral Sea

Ecology and Evolution
Aggregations are key events, supporting critical ecological and biological functions in many species. For highly mobile and elusive species, aggregations often provide the only feasible opportunities for research.
Ingo B. Miller, Richard Fitzpatrick, Kátya G. Abrantes, Bradley Norman, Simon J. Pierce, Mark V. Erdmann, Lisa A. Hoopes, Christine Dudgeon, Matthew D. Dunbabin, Alistair D. M. Dove, Robin J. Beaman, Samantha D. Reynolds, Christopher Rohner, Samuel M. Williams, David Paton, Sonny Lewis, Adam Barnett   +16 more
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Multi-constellation GBAS: how to benefit from a second constellation [PDF]

, 2016
In this paper we analyze and discuss the impact of ionospheric scintillations and multipath on the availability of the current single-frequency single-constellation Ground Based Augmentation System (GBAS).
Michael Felux, Mihaela-Simona Circiu, Circiu, Mihaela-Simona, Felux, Michael, Maria Caamano, Caamano, Maria, Gerbeth, Daniel, Daniel Gerbeth   +7 more
core   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

S192: SINGLE-CELL RNA PROFILING OF MYELOFIBROSIS PATIENTS REVEALS PELABRESIB-INDUCED DECREASE OF MEGAKARYOCYTIC PROGENITORS AND NORMALIZATION OF CD4+ T CELLS IN PERIPHERAL BLOOD

HemaSphere, 2022
O. Zavidij, N. J. Haradhvala, R. Meyer, J. Cui, S. Verstovsek, S. Oh, A. Mead, P. Taverna   +7 more
doaj   +1 more source