Results 51 to 60 of about 34,233 (259)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Spatial Constellation Design for MIMO Visible Light Communication Based on the Optimal Geometric Shaping

open access: yesIEEE Photonics Journal
As a wireless communication which combines illumination and communication, visible light communication (VLC) has attracted great attention. In indoor VLC systems, multiple illumination devices are commonly employed, forming a natural multi-input multi ...
Jia-Ning Guo, Jian Zhang
doaj   +1 more source

New Design of Constellation and Bit Mapping for Dual Mode OFDM-IM

open access: yesIEEE Access, 2019
Dual mode orthogonal frequency division multiplexing with index modulation (DM-OFDM-IM) is recently proposed, where the subcarriers within each subblock are divided into two groups, which are modulated by two distinguishable signal constellations.
Kee-Hoon Kim, Hosung Park
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Design of an Orbital Infrastructure to Guarantee Continuous Communication to the Lunar South Pole Region

open access: yesAerospace
The lunar south pole has gained significant attention due to its unique scientific value and potential for supporting future human exploration. Its potential water ice reservoirs and favourable conditions for long-term habitation make it a strategic ...
Nicolò Trabacchin, Giacomo Colombatti
doaj   +1 more source

A novel design on multi-layer satellite constellation network

open access: yes上海师范大学学报. 自然科学版, 2016
With the increasing demand of space technology,the traditional single layer satellite constellation network is restricted in the development of future space technology because of its simple structure.For this reason,more and more researchers have carried
LI Lianqiang   +4 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Design of double layer satellite constellation based on distributed satellite clusters

open access: yesDianxin kexue, 2018
Nowadays,the land communication system is unable to support the complex information needs,and realizing global seamless coverage and high capacity through space information network is anticipated.The existing satellite network is mainly composed of ...
Ji JIANG, Mugen PENG, Wenbo WANG
doaj  

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