Results 31 to 40 of about 56,129 (309)
HOPS is an essential constituent of centrosome assembly [PDF]
Cell Cycle, 2008 Centrosomes direct microtubule organization during cell division. Aberrant number of centrosomes results from alteration of its components and leads to abnormal mitoses and chromosome instability. HOPS is a newly discovered protein isolated during liver regeneration, implicated in cell proliferation.
PIERONI, STEFANIA +8 more
openaire +3 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
FEBS Letters, EarlyView.The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile +8 more
wiley +1 more source
The Varna representatives in the Constituent Assembly in 1879 [PDF]
, 2019 The first Bulgarian assembly was established in Tarnovo in 1879. Constituent Assembly elections were held in Bulgaria between 1 and 30 January 1879, although only 117 of the 231 members of the Assembly were elected during this period.
Nikolova, Mariyana; Regional Museum of History
core +1 more source
Elections to All-Russian Constituent Assembly in Terek Region: March — December 1917
Научный диалогThis article examines the elections to the Constituent Assembly of 1917 in the Terek region. The study of this process provides valuable historical insights that can inform contemporary electoral practices, thus representing a significant scholarly issue.
S. V. Darchieva
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Why the Jammu & Kashmir constituent assembly debates matter [PDF]
, 2021 This article highlights the significance of the J&K Constituent Assembly Debates for constitutional interpretation.
Deva, Zaid Abdul Mohsee Ul Latief
core +1 more source
Revista de Investigações ConstitucionaisConstituent power is understood as the power to bring about constitutional change. In modern constitutionalism, ‘the people’ are the legitimate holders of this power and they can exercise their constituent power to write a new constitution.
Thais Andrade Brugnerotto, Ruth Houghton
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source