Results 31 to 40 of about 56,035 (261)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Revista de Investigações ConstitucionaisConstituent power is understood as the power to bring about constitutional change. In modern constitutionalism, ‘the people’ are the legitimate holders of this power and they can exercise their constituent power to write a new constitution.
Thais Andrade Brugnerotto, Ruth Houghton
doaj +1 more source
Towards ‘EuroNest 2.0’: What should the next European Parliament learn from its predecessor? CEPS Policy Brief No. 300, 1 October 2013 [PDF]
, 2013 The development and functioning of the EU-Eastern Partnership Parliamentary Assembly (EuroNest PA) is the focus of this Policy Brief, in which the authors argue that despite organising a number of meetings and adopting several resolutions in the past two
Vandecasteele, Bruno, Kostanyan, Hrant.
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Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Nepal: From Constitutional Monarchy to a Republican State (1990-2008)
Journal of International Studies, 2020 The peoples’ movement of 1990 was a great landmark in the history of modern Nepal for it ended the three-decades of the old dictatorial rule of the king and established a parliamentary system with the king as a nominal head of state. But unfortunately,
Tri Ratna Manandhar
doaj
Filament assembly of the C. elegans lamin in the absence of helix 1A
Nucleus, 2022 Lamins are the major constituent of the nuclear lamina, a protein meshwork underlying the inner nuclear membrane. Nuclear lamins are type V intermediate filaments that assemble into ~3.5 nm thick filaments.
Rebecca de Leeuw +3 more
doaj +1 more source
The National Constituent Assembly in the period of 1946 - 1948 [PDF]
, 2011 THE NATIONAL CONSTITUENT ASSEMBLY ABSTRACT The diploma thesis deals with the activity of The National Constituent Assembly in the period of 1946-1948.
Tkadlec, Jaroslav
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Constituent Assembly of Georgia and the Paris Peace Conference
, 2023 Article about Constituent Assembly of Georgia and the Paris Peace ...
Surguladze, Paata
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