Results 61 to 70 of about 54,888 (266)

Nepal: From Constitutional Monarchy to a Republican State (1990-2008)

Journal of International Studies, 2020
The peoples’ movement of 1990 was a great landmark in the history of modern Nepal for it ended the three-decades of the old dictatorial rule of the king and established a parliamentary system with the king as a nominal head of state. But unfortunately,
Tri Ratna Manandhar
doaj  

Research on assembly sequence planning and optimization of precast concrete buildings

Journal of Civil Engineering and Management, 2018
Due to more complex structure and increasing prefabrication rate of precast concrete buildings, the assembly order between their constituent components is getting more and more attention. In order to solve the assembly sequence planning and optimization (
Yaowu Wang, Zhenmin Yuan, Chengshuang Sun   +2 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Popular demands related to sports in the National Constituent Assembly of Brazil

Revista de Investigações Constitucionais, 2019
The objective was to analyze the popular suggestions related to sports and sports democratization made to the last Brazilian National Constituent Assembly, registered in the Computer Support System to the Constituent, electronic platform created to ...
Felipe Canan, Fernando Augusto Starepravo   +1 more
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Türk Siyasal Hayatında Danışma Meclisi / The Constituent Assembly in Turkish Political Life

İnsan&İnsan Bilim Kültür Sanat ve Düşünce Dergisi, 2019
Türkiye’deki siyasal hayata yön ve biçim verme noktasında tekrar ede gelen bir alışkanlık var. Normatif düzenlemeler yoluyla toplumsal hayatın çeşitli kesimlerindeki aktör ve bağlılarının yönlendirilebileceği doğrultusundaki peşin hüküm, her altüst oluş ...
Cengiz Sunay
doaj   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Employers’ Representation. Considerations Over a Symmetric Contract Model

Labour & Law Issues, 2018
This article retraces the discussion of the Constituent Assembly of Italy over the Article 39, recovering an "old" issue that is the legitimation of employers' associations in the legal system.
Micaela Vitaletti
doaj   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source