Results 41 to 50 of about 73,671 (260)
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
‘Too utopian’: Theories of Utopia in constituent power
Global ConstitutionalismThere is something utopian about constituent power, whether this is the unrealisable idea of “the people” or the world-building nature of constitutional change.
Ruth Houghton
doaj +1 more source
La soberanía nacional en la constitución de Cádiz
Revista de Derecho Político, 2011 En este trabajo se hace un cotejo entre el principio de soberanía nacional, propio del constitucionalismo (no de las llamadas «Constituciones» o «Leyes Fundamentales» del Antiguo Régimen) y la primera Constitución española, de1812.
Antonio Torres Del Moral
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Europe and Constituent Powers [PDF]
, 2019 The financial crisis has precipitated constitutional transformations and institutional shifts of power equilibrium both within and beyond domestic borders. Within Member States of the EU, the strengthening of the executive power has almost become a leitmotif as the safeguarding of austerity under the pretence of necessity and at the expense of ...
openaire +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
The complacency of legality: Constitutionalist vulnerabilities to populist constituent power
German Law Journal, 2019 What role do public law and liberal constitutionalism play in an era of political populism? This article approaches this question by exploring the concept of constituent power in the light of recent constitutional developments in countries with populist ...
Julian Scholtes
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Rousseau, Theorist of Constituent Power
Oxford Journal of Legal Studies, 2016 © The Author 2016. Rousseau has always had an uncertain relationship with the theory of constituent power. On the one hand, his distrust of political representation and support for popular sovereignty seem consistent with the idea of the people as a legally unlimited constitution-maker.
openaire +2 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source