Results 51 to 60 of about 578,456 (293)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CONSTITUENT POWER

, 2017
This chapter seeks to recover an alternative theory of sovereignty as constituent power that significantly departs from the canonical paradigm of command in order to investigate its democratic implications. The first section traces the beginnings of the concept, from the etymological meanings of the Latin verb “to constitute” to its initial medieval ...
openaire   +2 more sources

Isospin-Violating Meson-Nucleon Vertices as an Alternate Mechanism of Charge-Symmetry Breaking [PDF]

, 1995
We compute isospin-violating meson-nucleon coupling constants and their consequent charge-symmetry-breaking nucleon-nucleon potentials. The couplings result from evaluating matrix elements of quark currents between nucleon states in a nonrelativistic ...
A. Coon, A. Gersten, A.G. Williams, A.N. Mitra, A.W. Thomas, B. Holzenkamp, C. J. Horowitz, C. Yakin, C.-Y. Cheung, D.B. Lichtenberg, E.M. Henley, E.M. Henley, E.M. Henley, F.J. Ernst, G. Krein, G.A. Miller, G.A. Miller, H.B. O'Connell, J. Piekarewicz, J. Piekarewicz, J. Piekarewicz, J.D. Walecka, J.J. Sakurai, K. Maltman, K.L. Mitchell, L. Ge, L. Ge, L.D. Knutson, L.D. Knutson, L.K. Morrison, L.M. Barkov, M. Beyer, M. Gell-Mann, M.J. Iqbal, M.J. Iqbal, R. Machleidt, R. Machleidt, R.K. Bhaduri, R.V. Reid, S. Gardner, S. Gardner, S.A. Coon, S.E. Vigdor, T. Goldman, T. Goldman, T. Hatsuda, Y. Nambu   +46 more
core   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Analytic formulas for frequency and size dependence of absorption and scattering efficiencies of astronomical polycyclic aromatic hydrocarbons

, 2012
In a series of two recent papers, the frequency and size distribution dependence of extinction spectra for astronomical silicate and graphite grains was analyzed by us in the context of MRN type interstellar dust models.
Ashim K. Roy, Cardelli, Cecchi-Pestellini, Donn, Draine, Draine, Draine, Fitzpatrick, Klacka, Li, Li, Li, Mathis, Pendorf, Platt, Pritesh Ranadive, Ranjan Gupta, Roy, Roy, Subodh K. Sharma, Weingartner   +20 more
core   +1 more source

Warm molecular hydrogen in the Spitzer SINGS galaxy sample [PDF]

, 2007
(simplified) Results on the properties of warm H2 in 57 normal galaxies are derived from H2 rotational transitions, obtained as part of SINGS. This study extends previous extragalactic surveys of H2, the most abundant constituent of the molecular ISM, to
Aalto S., B. T. Draine, Bajaja E., Braine J., Burton M. G., C. Bot, C. W. Engelbracht, Contini T., D. A. Dale, D. Calzetti, D. J. Hollenbach, Desert F. X., E. J. Murphy, E. Schinnerer, Elfhag T., F. Walter, G. Helou, Gatley I., Giard M., H. Roussel, Israel F. P., Israel F. P., J. D. Smith, Knapen J. H., Kohno K., Kohno K., L. Armus, Leon S., Lepp S., M. D. Thornley, Mauersberger R., Moorwood A. F., Moorwood A. F., Nakanishi H., Nishiyama K., Pagel B. E., Planesas P., Puxley P. J., R. C. Kennicutt, Sage L. J., Sage L. J., Shioya Y., Sofue Y., Strong A. W., Tacconi L. J., Valentijn E. A., Voit G. M., Wiklind T., Wilgenbus D.   +48 more
core   +4 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

‘Too utopian’: Theories of Utopia in constituent power

Global Constitutionalism
There is something utopian about constituent power, whether this is the unrealisable idea of “the people” or the world-building nature of constitutional change.
Ruth Houghton
doaj   +1 more source

La soberanía nacional en la constitución de Cádiz

Revista de Derecho Político, 2011
En este trabajo se hace un cotejo entre el principio de soberanía nacional, propio del constitucionalismo (no de las llamadas «Constituciones» o «Leyes Fundamentales» del Antiguo Régimen) y la primera Constitución española, de1812.
Antonio Torres Del Moral
doaj   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source