Results 61 to 70 of about 73,671 (260)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Identity Politics and the Militarisation of Constitutional Law

open access: yesAthena
In this article, I shall focus on the legal consequences of one of the most obvious features of populisms: identity politics. In particular, I shall explore how populists in power use constitutional law to identify and fight the alleged enemy, thus ...
Giuseppe Martinico
doaj   +1 more source

The constituent power and transitional justice in Brazil

open access: yesRevista do Direito Público, 2015
This article discusses two major fundamental theoretical issues in the formation of the modern state that are intertwined. The production of new constitutions, the change of the rule of recognition that allows the entry of statutes in the legal system as
Bruno Meneses Lorenzetto, Katya Kozicki
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

South Africa’s social contract: the Economic Freedom Fighters and the rise of a new constituent power?

open access: yesActa Academica, 2018
Taking the South African constitution as an eminent symbol of the South African social contract, and noting the opinion of many that the contract has failed to deliver, this article explores the concept of the social contract in South Africa by ...
Rachel Adams
doaj   +3 more sources

Pantonomy: towards a new ontology of the social in the context of radical interdependence

open access: yesИнтеллект. Инновации. Инвестиции
The social and political sciences of the Modern era and modernity were built on the foundation of the binary opposition «autonomy – heteronomy», which is currently undergoing a deep crisis.
A. V. Markov, O. A. Shtayn
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

Can ‘the people’ speak in one voice? The problem of collective speech in the debate on constituent power and constitutionalism

open access: yesGlobal Social Challenges Journal
Recent writings on constituent power insist that ‘the people’ cannot speak in one voice without widespread violence and deceit. Yet reform-minded constitutionalists are reluctant to abandon a concept that can legitimate deep change, so look for ways to ...
Catherine Frost
doaj   +1 more source

The Aporias of the Vicious Circle in A Political Beginning: Reflections on H. Arendt’s Thoughts on the Foundation of a Polity

open access: yesProblemos, 2018
[full article, abstract in English; abstract in Lithuanian] Modern revolution as the beginning of founding a new political order has to confront the vicious circle inhered in all beginnings: in so far as it is the beginning, where does its principle ...
Zhang Yan, Gao Song
doaj   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

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