Results 61 to 70 of about 10,381 (250)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Élisée Reclus et les États-Unis

Terra Brasilis, 2016
Comment les convictions intimes influencent-elles l’écriture d’une œuvre scientifique ? Leur caractère « subjectif » permet-il de franchir les préjugés du temps et ceux des collègues, pour enrichir le savoir « objectif » par un travail original ?
Ronald Creagh
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

L’accentuation des composés : une histoire de relations

Anglophonia
This paper looks at compound word stress in pronouncing dictionaries from the 18th century through to the present day (Walker, 1791; Jones, 1963, 2011; Wells, 1991, 2008), as well as the online version of the Oxford English Dictionary.
Susan Moore Mauroux, Nicolas Trapateau
doaj   +1 more source

Thematic principle and questions for the reading of chronicles: A proposal of ordering and sequencing

Calidoscópio, 2018
The present study aims at putting forward a theoretical-methodological proposal of ordering and sequencing of questions for the reading of the text genre Chronicle, with the latter being adopted in Middle School.
Ângela Francine Fuza, Renilson José Menegassi   +1 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

André Vitalis, L’Incertaine Révolution numérique [PDF]

, 2017
Comme le titre l’indique clairement, le dernier livre d’André Vitalis ne s’associe pas à la vulgate ou aux chantres de la révolution numérique. Il propose, dans un volume restreint et de lecture aisée, une vaste revue de la littérature, nourrie aussi de ...
Tétu, Jean-François
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Too soon to know: exploring the conditions of existence of the constituent power

, 2023
This Afterword takes up the challenge presented by Sergio Verdugo’s Foreword and explores how Costantino Mortati formulated the concept of material constitution to address the questions raised by both Verdugo and proponents of constituent power theory ...
Romeo, Graziella
core   +1 more source

Evaluating theories: Counting nodes and the question of constituency

Language Under Discussion, 2019
This paper is a reply to Timothy Osborne’s paper Tests for constituents: What they really reveal about the nature of syntactic structure that appeared 2018 in Language under Discussion. This paper discusses how constituent tests work and why it is no problem if they are not applicable.
openaire   +2 more sources