Results 71 to 80 of about 10,381 (250)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

ANALYSE DES INTERFÉRENCES LINGUISTIQUES CHEZ DES APPRENANTS GAMBIENS DE FRANÇAIS LANGUE ÉTRANGÈRE (FLE) : POUR UNE APPROCHE DE LA LINGUISTIQUE CONTRASTIVE [PDF]

Studii de gramatică contrastivă, 2018
: Les interférences constituent les premières hypothèses émises par l’apprenant dans son appropriation d`un nouveau système linguistique. Elles sont réalisées par analogie et /ou habitude prise en langue source.
Ndèye Maty Paye
doaj  

Marquage et politique linguistique urbaine. L’exemple de la ville de Kénitra.

Revue des Langues, Cultures et Sociétés, 2017
Le présent travail s’intéresse principalement à la politique linguistique urbaine et la façon avec laquelle elle est pensée à Kénitra.  S’appuyant sur une démarche empirico-inductive, l’objectif de ce travail est de relever et d’expliquer comment se fait
Mehdi Haidar
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Grammatical properties of pronouns and their representation : an exposition

, 2010
This volume brings together a cross-section of recent research on the grammar and representation of pronouns, centering around the typology of pronominal paradigms, the generation of syntactic and semantic representations for constructions containing ...
Wiese, Heike, Simon, Horst J.
core  

Satisfying Questions

, 2019
In this paper we first combine and refine the semantics of questions and answers (Groenendijk and Stokhof 1984) and the logic of interrogation (Groenendijk 1999) in order to deal with topical restriction, constituent answerhood and conditional questions ...
Dekker, Paul
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Identifying high-impact sub-structures for convolution kernels in document-level sentiment classification [PDF]

, 2012
Convolution kernels support the modeling of complex syntactic information in machine-learning tasks. However, such models are highly sensitive to the type and size of syntactic structure used.
Shouxun, Lin, Foster, Jennifer, Liu, Qun, He, Yifan, Tu, Zhaopeng, van Genabith, Josef   +5 more
core  

Prosodic structure of focus in Persian [PDF]

زبان پژوهی
IntroductionThis research investigated the intonational patterns of the focused constituents in a number of Persian language utternaces in the framework of autosegmental-metrical theory.
Mahrokh Monsef, Batool Alinezhad, Vali Rezai   +2 more
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source