Results 81 to 90 of about 46,692 (260)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

The constitutive equation gap method [PDF]

, 2011
This chapter discusses constitutive equation gap method used for identification of materials constitutive parameters. It involves a comparison of given stress field and displacement field to a computed stress field generated by using an initial set of ...
Syed Muhammad, Kashif
core  

MODELING THE HOT DEFORMATION FLOW CURVES OF API X65 PIPELINE STEEL USING THE POWER LAW EQUATION

Iranian Journal of Materials Science and Engineering, 2016
Till now, different constitutive models have been applied to model the hot deformation flow curves of different materials. In this research, the hot deformation flow stress of API X65 pipeline steel was modeled using the power law equation with strain ...
M. Rakhshkhorshid
doaj  

Constitutive behavior and microstructural evolution of FeMnSiCrNi shape memory alloy subjected to compressive deformation at high temperatures

Materials & Design, 2019
Constitutive behavior and microstructural evolution of FeMnSiCrNi shape memory alloy (SMA) subjected to compressive deformation at high temperatures were investigated based on the different deformation conditions.
Shuyong Jiang, Yu Wang, Yanqiu Zhang, Xiaodong Xing, Bingyao Yan   +4 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Identification of plastic constitutive parameters at large deformations from three dimensional displacement fields [PDF]

, 2011
The aim of this paper is to provide a general procedure to extract the constitutive parameters of a plasticity model starting from displacement measurements and using the Virtual Fields Method.
Fabrice Pierron, Rossi, Marco, Marco Rossi, F. Pierron, Pierron, Fabrice   +4 more
core   +1 more source

A Modified Eyring Equation for Modeling Yield and Flow Stresses of Metals at Strain Rates Ranging from 10−5 to 5 × 104 s−1

Advances in Materials Science and Engineering, 2015
In several industrial applications, metallic structures are facing impact loads. Therefore, there is an important need for developing constitutive equations which take into account the strain rate sensitivity of their mechanical properties.
Ramzi Othman
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Constitutive Equation of Hot Deformation of ZL114A Alloy

Journal of Harbin University of Science and Technology, 2018
At the condition of deformation temperature of 350 ～ 470 ℃，strain rate of 0. 001 ～ 10 s －1， deformation of 50%，hot compression tests for ZL114A alloy were carried out by Gleeble-1500D thermal simulation testing machine. The characteristics of true stress-
KANG Fu-wei, ZHANG Ji-min, FAN De-zhi, WANG Shan-shan   +3 more
doaj   +1 more source