Results 111 to 120 of about 1,763,243 (270)

NUMERICAL MODELLING OF DISCONTINUOUS ROCK MASS IN THE ELASTIC DOMAIN

Rudarsko-geološko-naftni Zbornik, 1995
Constitutive relationships of rock materials are an important component of the numerical modelling, it is not possible to find a generally acceptable constitutive law for rock materials, because of their complex nature.
Biljana Kovačević-Zelić, Davorin Kovačić , Slavko Vujec   +2 more
doaj  

Experimental and numerical investigations of sheet AA6082 formability and B-pillar forming under HFQ conditions

Manufacturing Review
Assessing and predicting formability of a material have significant importance for forming process design and optimisation. In this paper, formability of AA6082 under various conditions were investigated through biaxial tensile tests, and the results ...
Li Jiaqi, Shi Zhusheng, Zhang Ruiqiang, Lin Jianguo   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Advancing Fire–Structural Performance Assessment of Timber Structures with Wood^ST: Supporting Code and Standard Development and Product Innovation

Buildings
As timber construction continues to expand toward taller and larger buildings, ensuring structural resilience under fire conditions requires advanced fire–structural performance assessment approaches.
Zhiyong Chen, Christian Dagenais
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

NUMERICAL MODELLING OF ELASTO-VISCOPLASTIC BODNER-PARTOM CONSTITUTIVE EQUATIONS

TASK Quarterly, 2005
The aim of the paper is to propose an FE procedure for static and dynamic nonlinear analysis including elasto-viscoplastic constitutive equations of the Bodner-Partom model. Basic equations of the constitutive model are given with the flow graph used in
ANDRZEJ AMBROZIAK
doaj  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Mechanical properties of whole-body human bones: a review

Materials Research Express
The mechanical properties of hard tissues, particularly bones, are fundamental to understanding human biomechanics, injury mechanisms, and the development of effective mitigation strategies.
Shivam Verma, Gurpreet Singh, Akhilesh Choudhary, Shabir Hussain, Arnab Chanda   +4 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source