Results 91 to 100 of about 16,380 (285)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Constitutive Rules of Precedent
, 2023 © 2022. This document is made available under the CC-BY-SA 4.0 license http://creativecommons.org/licenses/by-sa/4.0/ This document is the published version of a published work that appeared in final form in Revus, Journal for constitutional theory and ...
Nuñez Vaquero, A.
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
, 2013 This paper presents a review of creep deformation and rupture mechanisms of low Cr-Mo alloy for the development of its creep damage constitutive equations under lower stress.
Xu, Qiang +4 more
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Sport technology, rules, and the internal goods of sport
Acta Universitatis Carolinae KinanthropologicaThis paper explores the role of technology in sports development. Based on three examples – artificial surfaces in field hockey and football (including the Jabulani football); javelins and vault-poles; and running shoes and swimsuits – a criterion is ...
Jim Parry, Irena Martínková
doaj +1 more source
Can constitutive rules create a practice?
Revista Opinião Jurídica (Fortaleza), 2016 The author investigates the role of constitutive rules in the construction of social reality. He denies that constitutive rules are a sufficient condition of a practice such as a chess game. To create a new practice with rules, it is necessary that there already be the grammar of this practice, that is, the sense of this practice (for example, the ...
openaire +5 more sources
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Rules of procedure of the assembly and the executive council, statutes of the commission and rules of procedure of the permanent representatives’ committee [PDF]
, 2002 Rules of procedureThe Assembly of the Union, Having regard to the Constitutive Act of the African Union, and in particular Article 8,has adopted these rules of ...
African union
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Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source