Results 91 to 100 of about 200,600 (296)

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Ambiguity in a Dialectical Perspective

open access: yesInformal Logic, 2001
The distinction between constitutive and regulative rules is applied to rules for critical discussion that have to do with the use of ambiguous expressions.
Jan Albert van Laar
doaj   +1 more source

CONSTITUTION AS A STIMULATION FACTOR OF CONSTRUCTION SOCIOCULTURAL CAPITAL

open access: yesSTED Journal, 2021
In all areas of society, it is necessary to actively and continuously act on unique (constitutive) rules that apply equally to all and perform non-selective and unprivileged regulation, coordination, organization and limitation of human behavior.
Nikša Grgurević, Saša Mitrić
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Towards the Emergence of Constitutive Rules for Equitable Agribusiness Value Chains [PDF]

open access: yes
Replaced with revised version of paper 10/18/07.Agribusiness,
Bourgeois, Robin
core   +1 more source

Instituted or Embedded? Legal, Fiscal and Economic Institutionalisation of Markets [PDF]

open access: yes, 2009
Recent debates in economic sociology have raised questions about the significance of law in the economy, and specifically the role of law in the operation of markets.
Harvey, M
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Does Ontogenesis of Social Ontology Start with Pretence?

open access: yesPhenomenology and Mind, 2016
Rakoczy and Tomasello follow Searle in claiming that rule games need status function assignment and constitutive rules. But, in the case of pretend play, it is not easy to put together these notions with the natural world knowledge necessary to engage in
Gaetano Albergo
doaj   +1 more source

Mimetic Constitutive Rules [PDF]

open access: yesSSRN Electronic Journal, 2012
This paper deals with the question of how constitutive rules in Searle’s sense can be subject to definite constraints, or boundaries. Three kinds of boundaries to institutional constitution are here identified: ontological, structural, and pragmatic. All these kinds of boundaries to some extent depend on the context of the broader social practice for ...
openaire   +3 more sources

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