Results 71 to 80 of about 13,776 (256)
Ambiguity in a Dialectical Perspective
The distinction between constitutive and regulative rules is applied to rules for critical discussion that have to do with the use of ambiguous expressions.
Jan Albert van Laar
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CONSTITUTION AS A STIMULATION FACTOR OF CONSTRUCTION SOCIOCULTURAL CAPITAL
In all areas of society, it is necessary to actively and continuously act on unique (constitutive) rules that apply equally to all and perform non-selective and unprivileged regulation, coordination, organization and limitation of human behavior.
Nikša Grgurević, Saša Mitrić
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CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
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Mimetic Constitutive Rules [PDF]
This paper deals with the question of how constitutive rules in Searle’s sense can be subject to definite constraints, or boundaries. Three kinds of boundaries to institutional constitution are here identified: ontological, structural, and pragmatic. All these kinds of boundaries to some extent depend on the context of the broader social practice for ...
openaire +3 more sources
Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Does Ontogenesis of Social Ontology Start with Pretence?
Rakoczy and Tomasello follow Searle in claiming that rule games need status function assignment and constitutive rules. But, in the case of pretend play, it is not easy to put together these notions with the natural world knowledge necessary to engage in
Gaetano Albergo
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Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Content and Meaning Constitutive Inferences
DOI: http://doi.org/10.26333/sts.xxxiii1.03 A priori theories of justification of logic based on meaning often lead to trouble, in particular to issues concerning circularity. First, I present Boghossian’s a priori view.
Maria Dolores Garcia-Arnaldos
doaj
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source

