Results 41 to 50 of about 16,380 (285)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Optimal Data-Generation Strategy for Machine Learning Yield Functions in Anisotropic Plasticity

open access: yesFrontiers in Materials, 2022
Trained machine learning (ML) algorithms can serve as numerically efficient surrogate models of sophisticated but numerically expensive constitutive models of material behavior. In the field of plasticity, ML yield functions have been proposed that serve
Ronak Shoghi, Alexander Hartmaier
doaj   +1 more source

The norm of assertion: a ‘constitutive’ rule? [PDF]

open access: yesInquiry, 2019
According to an influential hypothesis, the speech act of assertion is subject to a single ‘constitutive’ rule, that takes the form: ‘One must: assert that p only if p has C’. Scholars working on assertion interpret the assumption that this rule is ‘constitutive’ in different ways.
openaire   +2 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

A thermoviscoelastic finite deformation constitutive model based on dual relaxation mechanisms for amorphous shape memory polymers

open access: yesInternational Journal of Smart and Nano Materials, 2023
This paper proposes a new thermoviscoelastic finite deformation model incorporating dual relaxation mechanisms to predict the complete thermo-mechanical response of amorphous shape memory polymers.
Hao Duan   +4 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Constitutional Amendment Rules

open access: yesSSRN Electronic Journal, 2011
The difficulty of constitutional amendment, in most contexts, clearly depends on both the formal rules governing amendment and a variety of other factors. This chapter explores the significance one such non-textual factor: the size, or scale, of a polity.
Dixon, Rosalind, Holden, Richard T.
openaire   +2 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Fractional-Order Elastoplastic Modeling of Sands Considering Cyclic Mobility

open access: yesJournal of Marine Science and Engineering, 2021
Seabed soil may experience a reduction in strength or even liquefaction when subjected to cyclic loadings exerted by offshore structures and environmental loadings such as ocean waves and earthquakes.
Leiye Wu, Wei Cheng, Zhehao Zhu
doaj   +1 more source

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