Results 51 to 60 of about 495,604 (291)
Trends in Computational and Applied Mathematics, 2019 First and second order necessary optimality conditions of Karush-Kuhn-Tucker type are established for continuous-time optimization problems with equality and inequality constraints.
Moisés Rodrigues Cirilo Monte +1 more
doaj +1 more source
Human resources management simulation in the IT-labor market
Вісник Харківського національного університету імені В.Н. Каразіна: Серія Економіка, 2021 The article developed a mathematical model of personnel management, taking into account the specifics of the activities of IT companies. The relevance of this study is due to the fact that the tasks of personnel management are subjective.
I. Ivchenko, L. Lingur, T. Filatova
doaj +1 more source
Constraint qualifications in nonsmooth multiobjective optimization problem
, 2017 A multiobjective optimization problem (MOP) with inequality and equality constraints is considered where the objective and inequality constraint functions are locally Lipschitz and equality constraint functions are differentiable.
Manjari Srivastava, Rekha Gupta
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
On the uniqueness of the optimal solution in linear programming
Journal of Numerical Analysis and Approximation Theory, 2006 In this paper numerous necessary and sufficient conditions will be given for a vector to be the unique optimal solution of the primal problem, as well as for that of the dual problem, and even for the case when the primal and the dual problem have unique
Peter Szilágyi
doaj +2 more sources
Critical analysis of entrepreneurial spirit, attitudes and perceptions of young South Africans in KwaZulu-Natal province [PDF]
Problems and Perspectives in Management, 2016 Positive entrepreneurial spirit, attitudes and perceptions among the communities, with specific reference to young South Africans in KwaZulu-Natal province, can improve the lives of many young people and alleviate poverty and unemployment challenges in ...
Lawrence Mpele Lekhanya
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source