Results 61 to 70 of about 495,604 (291)
London Review of Education, 2017 The distinction between external assessment and internal assessment underpins a major reform to vocational qualifications underway in England. To be approved by the Department for Education, vocational qualifications must now include a minimum ...
doaj +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
MathematicsIn this article, we investigate a class of non-smooth semidefinite multiobjective programming problems with inequality and equality constraints (in short, NSMPP). We establish the convex separation theorem for the space of symmetric matrices.
Balendu Bhooshan Upadhyay +2 more
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Reimagining academic identities in response to research demands at Universities of Technology
Critical Studies in Teaching and Learning, 2020 In the last volume of this journal, Garraway and Winberg called for a reimagination of Universities of Technology (UoT) within the South African higher education system.
Thobani Gumbi, Sioux McKenna
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FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Sequential approximate optimality conditions for a constrained convex vector minimization problem and application to multiobjective fractional programming problem [PDF]
Iranian Journal of Numerical Analysis and OptimizationThe aim of this paper is to establish sequential necessary and sufficient approximate optimality conditions for a constrained convex vector mini-mization problem without any constraint qualifications, characterizing the approximate proper and weak ...
A. Ed-dahdah +3 more
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