Results 81 to 90 of about 495,604 (291)
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Analele Stiintifice ale Universitatii Ovidius Constanta: Seria MatematicaIn this paper it is introduced a new generalized pseudo-operation with one parameter of the following form: x ⊕ɛ y = h−1(h(x) + ɛh(y)), where h is an n vector-valued continuous function, defined on a subset H of ℝn and possessing an inverse function h−1,
Bobe Alexandru +2 more
doaj +1 more source
Constraint Design Rewriting [PDF]
, 2013 We propose an algebraic approach to the design and transformation of constraint networks, inspired by Architectural Design Rewriting. The approach can be understood as (i) an extension of ADR with constraints, and (ii) an application of ADR to the design
Lluch-Lafuente, Alberto +2 more
core
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
A tutorial on properties of the epigraph reformulation
EURO Journal on Computational OptimizationThis paper systematically surveys useful properties of the epigraph reformulation for optimization problems, and complements them by some new results. We focus on the complete compatibility of the original formulation and the epigraph reformulation with ...
Oliver Stein
doaj +1 more source
Versatile vector tools for efficient protein screening across multiple expression systems
FEBS Open Bio, EarlyView.A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu +5 more
wiley +1 more source
International Journal of Analysis and Applications, 2020 In this paper, we are concerned with one of the difficult class of optimization problems called the interval-valued optimization problem with vanishing constraints.
Izhar Ahmad +2 more
doaj
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Pathways and pitfalls: a qualitative study of student experiences in biomedical science education
FEBS Open Bio, EarlyView.Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell +8 more
wiley +1 more source