Results 101 to 110 of about 1,744,639 (315)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Houria II: A Solver For Hierarchical Constraint Systems. Planning of Lexicographic Satisfied Count Best Case Better Graph for Equational Constraints.

open access: yes, 1995
Equational constraints are useful in many applications such as user interface and simulation packages. In many situations, it is desirable to be able to state both hard and soft constraints. The hard constraints must hold, and the soft constraints should
Equational Constraints   +3 more
core  

Symbolic Constraints in Constructive Geometric Constraint Solving

open access: yesJournal of Symbolic Computation, 1997
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Christoph M. Hoffmann   +1 more
openaire   +2 more sources

Versatile vector tools for efficient protein screening across multiple expression systems

open access: yesFEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu   +5 more
wiley   +1 more source

Analysis of women participation in farmer group activities in Kwara State, Nigeria

open access: yesAgricultura Tropica et Subtropica, 2019
The level of access of women to production resources can be enhanced through their active membership and participation in farmers’ associations. However, most farmer-groups in Nigeria are male-dominated.
Omotesho Kemi Funmilayo   +3 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

open access: yesFEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin   +12 more
wiley   +1 more source

Internal financial constraints, external financial constraints, and investment choice: Evidence from a panel of UK firms [PDF]

open access: yes
This paper uses a panel of 24184 UK firms over the period 1993-2003 to study the extent to which the sensitivity of investment to cash flow differs at firms facing different levels of internal and external financial constraints.
Alessandra Guariglia
core  

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Optimization with multivariate conditional value-at-risk constraints [PDF]

open access: yes, 2013
For many decision making problems under uncertainty, it is crucial to develop risk-averse models and specify the decision makers' risk preferences based on multiple stochastic performance measures (or criteria). Incorporating such multivariate preference
Noyan, Nilay, Rudolf, Gabor
core   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

open access: yesFEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose   +9 more
wiley   +1 more source

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