Results 81 to 90 of about 2,249,985 (314)
Psicologia & Sociedade, 2008 Partindo do referencial da RedSig e da filosofia espinosana, este trabalho objetivou investigar os modos de vida produzidos na e pela prisão, apostando no conhecimento de alguns circunscritores do processo de constituição de pessoas que habitam os ...
Gilead Marchezi Tavares +1 more
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Proceedings Australian Workshop on Constraints
, 1998 Constraints have emerged as the basis of a representational and computational paradigm that draws from many disciplines and can be brought to bear on many problem domains.
Maher, Michael
core
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Scheduling Under Labour Resource Constraints
, 2015 In this paper we introduce an optimization problem extracted from an industrial application: the scheduling problem under labour constraints. After giving a short summary of the origins of this problem and its mathematical formulation, the different ...
De Souza C.C. +3 more
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Addressing Dependent Data in Constrained Optimization Problems: A WOA-based Algorithm [PDF]
International Journal of Industrial Electronics, Control and OptimizationOptimization algorithms are widely used in various fields to find the best solution to a problem by minimizing or maximizing an objective function, subject to certain constraints.
Asieh Ghanbarpour +2 more
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RNA‐related functions of BRCA2 in transcription, replication, and genome stability
FEBS Letters, EarlyView.Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda +2 more
wiley +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Control over the deployment of an orbital tether system of great length
Вестник Самарского университета: Аэрокосмическая техника, технологии и машиностроение, 2017 Control of deploying an extended tether system into the vertical position is considered in the paper. It is assumed that in the initial state the system consisting of two space vehicles moves in a circular Earth orbit. We propose nominal control programs
Ch. Wang, Yu. M. Zabolotnov
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Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source