Results 81 to 90 of about 1,744,639 (315)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Proceedings Australian Workshop on Constraints
, 1998 Constraints have emerged as the basis of a representational and computational paradigm that draws from many disciplines and can be brought to bear on many problem domains.
Maher, Michael
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Psicologia & Sociedade, 2008 Partindo do referencial da RedSig e da filosofia espinosana, este trabalho objetivou investigar os modos de vida produzidos na e pela prisão, apostando no conhecimento de alguns circunscritores do processo de constituição de pessoas que habitam os ...
Gilead Marchezi Tavares +1 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Scheduling Under Labour Resource Constraints
, 2015 In this paper we introduce an optimization problem extracted from an industrial application: the scheduling problem under labour constraints. After giving a short summary of the origins of this problem and its mathematical formulation, the different ...
De Souza C.C. +3 more
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CLASSICAL DESCRIPTIONS OF THE GEOMETRODYNAMICS OF CHARGED BLACK HOLES
Odessa Astronomical Publications, 2019 Analytical aspects of the classical geometrodynamics of charged black holes are considered. The classical model of the charged BHs is the spherically symmetric configuration of the electromagnetic and gravitational fields in GR.
V. D. Gladush
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source