Results 71 to 80 of about 917,424 (269)
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Psicologia & Sociedade, 2008 Partindo do referencial da RedSig e da filosofia espinosana, este trabalho objetivou investigar os modos de vida produzidos na e pela prisão, apostando no conhecimento de alguns circunscritores do processo de constituição de pessoas que habitam os ...
Gilead Marchezi Tavares +1 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
CLASSICAL DESCRIPTIONS OF THE GEOMETRODYNAMICS OF CHARGED BLACK HOLES
Odessa Astronomical Publications, 2019 Analytical aspects of the classical geometrodynamics of charged black holes are considered. The classical model of the charged BHs is the spherically symmetric configuration of the electromagnetic and gravitational fields in GR.
V. D. Gladush
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Addressing Dependent Data in Constrained Optimization Problems: A WOA-based Algorithm [PDF]
International Journal of Industrial Electronics, Control and OptimizationOptimization algorithms are widely used in various fields to find the best solution to a problem by minimizing or maximizing an objective function, subject to certain constraints.
Asieh Ghanbarpour +2 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Control over the deployment of an orbital tether system of great length
Вестник Самарского университета: Аэрокосмическая техника, технологии и машиностроение, 2017 Control of deploying an extended tether system into the vertical position is considered in the paper. It is assumed that in the initial state the system consisting of two space vehicles moves in a circular Earth orbit. We propose nominal control programs
Ch. Wang, Yu. M. Zabolotnov
doaj +1 more source