Results 71 to 80 of about 1,744,639 (315)
Selection of economically rational investments through cost benefit analysis [PDF]
Ekonomski Signali, 2022 Business decision making is an act of choosing between at least two competing simultaneously available investment alternatives. Cost benefit analysis enables direct and indirect measurement of all relevant costs and benefits expected in the future based ...
Dedović Nedeljka
doaj
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Adaptive governance for resilient local service delivery
Journal of Local Government Research and InnovationNo abstract available.
Ogochukwu I. Nzewi
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Financial constraints in China: firm-level evidence. [PDF]
This paper uses a unique micro-level data-set on Chinese firms to test for the existence of a "political-pecking order" in the allocation of credit. Our findings are threefold. Firstly, private Chinese firms are credit constrained while State-owned firms
Poncet, Sandra +2 more
core +6 more sources
Perspectives of the Antifa Movement in Cyprus
Partecipazione e ConflittoThe article examines two different leftist, Antifa actors in Cyprus, a political party and a societal group (i.e., an organized football fan group), in relation to two issues.
Yiannos Katsourides +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Control of a two-link manipulator using disturbance observer-based model predictive control
Nihon Kikai Gakkai ronbunshu, 2015 This paper addresses position and path-tracking problems of robot manipulators subject to constraints on both the magnitude and difference of the control input.
Toshiyuki SATOH +4 more
doaj +1 more source