Results 171 to 180 of about 13,464 (314)

Minimally Invasive Aortic Regurgitation Surgery: A Mouse Model of Volume Overload-Induced Cardiac Remodeling by Aortic Regurgitation. [PDF]

JACC Basic Transl Sci
Zhu J, Gao C, Wang Y.
europepmc   +1 more source

Senescent Cell Derived Artificial Vesicle‐Based Senolytic Sonovaccine Platform with Augmented Lymph Node Delivery and Antigen Cross‐Presentation Efficacy

Advanced Science, EarlyView.
A senolytic sonovaccine platform (SenoVac) is developed, in which senescent cell‐derived vesicles serve as broad senescent cell antigen reservior. The “2‐step” click chemistry strategy for effective lymph node delivery, and ultrasound‐triggered endosomal escape to boost cross‐presentation, ensures efficient senescent cell clearance and disease ...
Liang Zhang, Yubo Lai, Jia Wang, Lingling Liu, Jieyuan An, Mi Qu, Yuan Liang, Bijun Tan, Guodong Yang, Xuekang Yang, Lijun Yuan   +10 more
wiley   +1 more source

CXCL10 Regulates Pressure Overload-Induced Heart Failure. [PDF]

JACC Basic Transl Sci
Souza-Neto F, Le P, Abdrabbo M, Alamgir A, Wang H, Ferreira de Araujo N, Mikkila JL, Sanches B, Parthiban P, Moon R, Herman A, Adams AB, Prins KW, Guatimosim S, Schuldt N, Revelo XS, van Berlo JH.   +16 more
europepmc   +1 more source

Experimentally Altering the Compliance of Titin's Spring Region

, 2016
Chapter 1 of this work focuses on alternative splicing of titin as a proof of concept therapy for treating diastolic dysfunction and restrictive filling in a genetic murine model (Ttn^(ΔIAjxn)).
Bull, Mathew Michael
core  

How Advanced Artificial Intelligence Technologies Shape Drug–Drug and Drug–Target Interaction Modeling

Advanced Science, EarlyView.
This review explores the convergence of artificial intelligence technologies in modeling drug–drug and drug–target interactions. By evaluating advanced feature engineering, architectural innovations, and learning paradigms reveals shared evolutionary trends and critical challenges, such as cold‐start settings and shortcut learning.
Xin Sun, Tong Wang
wiley   +1 more source

Robotic-Assisted Laparoscopic Buccal Mucosal Graft Ureteroplasty and Ureteral Reim-plantation for Repair of Complex Ureteral Strictures Using the Modular Carina™ System. [PDF]

Int Braz J Urol
Han W, Li Z, Li Z, Han G, Zhang Z, Yang K, Li X.   +6 more
europepmc   +1 more source

Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects

Advanced Science, EarlyView.
Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu, Ke Wang, Kaizhong Lu, Tianlun Hou, Yuan Chen, Xian Wang, Hongchuan Jin   +6 more
wiley   +1 more source

Characterizing pancreatic cancer-associated fibroblast heterogeneity in vascular microphysiological systems. [PDF]

Angiogenesis
Blackledge CW, Gullion S, McCabe I, Van NNK, Hariharan A, Luan C, Peng XL, Polacheck WJ, Yeh JJ, Shelton SE.   +9 more
europepmc   +1 more source

Full‐Stack Architectures for Intelligent Brain‐Computer Interfaces

Advanced Science, EarlyView.
System‐level overview of brain–computer interfaces (BCIs), illustrating the integration of neural signal acquisition, wireless transmission, and adaptive decoding. Advanced electrode, tissue interfaces, energy‐efficient communication, and robust algorithms collectively enable stable signal quality, real‐time processing, and closed‐loop operation ...
Hee Kyu Lee, Hyun Bin Kim, Sang Uk Park, Janghoon Joo, Jinhong Min, Geumbee Lee, Joohoon Kang, Hyoyoung Jeong, Jae‐Young Yoo, Sang Min Won   +9 more
wiley   +1 more source

Giant saphenous vein graft aneurysm and associated constrictive pericarditis in a patient with prior CABG. [PDF]

Glob Cardiol Sci Pract
Larson EL, Hapuarachchy B, Aziz H.
europepmc   +1 more source