Results 171 to 180 of about 126,550 (315)

Targeting WDR12 Unleashes T‐Cell‐Mediated Antitumor Activity in Melanoma by Destabilizing CD276

Advanced Science, EarlyView.
WDR12 cooperates with the chaperonin subunit CCT7 to maintain CD276 stability on tumor cells, suppressing T‐cell activity and promoting immune escape. SU14813, a small‐molecule WDR12 inhibitor, reduces CD276 stability and relieves CD276‐mediated T‐cell suppression.
Jie Pan, Ruimin Chang, Meng Zhang, Qian Dong, Guanxiong Zhang, Xiang Chen, Mingliang Chen, Lixia Lu, Xiaowei Liang, Yeye Guo, Juan Su   +10 more
wiley   +1 more source

Model-based comparison of latency estimation methods for the pupillary light reflex. [PDF]

Sci Rep
Schepelmann M, Krojanski HG.
europepmc   +1 more source

Matrix Stiffness Induces Endothelial Network Senescence

Advanced Science, EarlyView.
Using a 3D human in vitro model that decouples mechanical stress from inflammatory or biochemical signals, matrix stiffening induces a senescence phenotype in endothelial networks. This mechano‐induced senescence activates Notch signaling, and pharmacologic Notch inhibition attenuates this stiffness‐induced senescence.
Jiyeon Song, Alexandra N. Rindone, Ya Guan, Connor D. Amelung, Prarthana Sanjay Daswani, Jennifer H. Elisseeff, Sharon Gerecht   +6 more
wiley   +1 more source

Histone Deacetylase 7 protects against pathologic cardiac hypertrophy. [PDF]

J Mol Cell Cardiol
Bu J, Hand SM, Guo S, Jang J, Li D.
europepmc   +1 more source

Forced exercise attenuates neuropathic pain in chronic constriction injury of male rat: an investigation of oxidative stress and inflammation

, 2017
Hossein Ali Safakhah,1,2 Nasroallah Moradi Kor,2,3 Atiyeh Bazargani,3 Ahmad Reza Bandegi,4 Hamid Gholami Pourbadie,5 Baharak Khoshkholgh-Sima,5 Ali Ghanbari2 1Department of Physiology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan ...
Khoshkholgh-Sima B, Safakhah HA, Ghanbari A, Moradi Kor N, Bandegi AR, Bazargani A, Gholami Pourbadie H   +6 more
core  

ZER1 Restrains Pressure Overload‐Induced Cardiac Remodeling by Targeting DVL2 for Gly/N‐Degron‐Dependent Degradation

Advanced Science, EarlyView.
Pressure overload suppresses cardiomyocyte ZER1, weakening CRL2Zer1‐mediated DVL2 degradation and allowing DVL2 accumulation. Elevated DVL2 activates CaMKII‐HDAC4‐MEF2C signaling, drives fetal gene reactivation, and promotes pathological remodeling.
Mingchao Jiang, Zhehao Lin, Lu Chen, Ying Ni, Jun Zhou, Wenjuan Zhang, Huilin Wang, Peifeng Ying, Xiu Lu, Kai Wang, Qingran Kong, Naxin Xu, Dingsheng Zhao, Jianwei Li, Guohui Zhong, Xingchen Meng, Sarkawt Hamad, Junmeng Zheng, Yuan Fu, Rongjiang Qin, Xuran Chu, Shangxuan Li, Youyou Li, Yili Wu, Yi Wang, Weihong Song, Yingxian Li, Shukuan Ling   +27 more
wiley   +1 more source

Osimertinib induces reversible cardiac dysfunction through the GATA4-MYLK3-MYL2 axis. [PDF]

Eur Heart J
Zhang K, Ayala A, Norambuena-Soto I, Agnihotri V, Shu T, Nenninger C, Wang Y, Echevarria B, Aboagye J, Huang K, Espitia-Corredor J, Wu X, Chen ZB, Deng Y, Perry JJP, Raz DJ, Yang H, Cheng P, Fu G, Wang ZV, Rhee JW.   +20 more
europepmc   +1 more source

Multiscale Circuit Architecture Associated With Memory Dysfunction in Temporal Lobe Epilepsy

Advanced Science, EarlyView.
A multiscale precision‐mapping framework reveals that memory impairment in temporal lobe epilepsy arises from the convergence of focal medial temporal pathology, strategic white matter disconnection, and limbic‐centered metabolic network dysfunction.
Jiajie Mo, Qiwen Yuan, Pengfei Zhang, Lin Sang, Zhong Zheng, Baotian Zhao, Xiu Wang, Chao Zhang, Wenhan Hu, Xiaoqiu Shao, Jianguo Zhang, Ruijin Yang, Kai Zhang   +12 more
wiley   +1 more source

Robotic-Assisted Laparoscopic Buccal Mucosal Graft Ureteroplasty and Ureteral Reim-plantation for Repair of Complex Ureteral Strictures Using the Modular Carina™ System. [PDF]

Int Braz J Urol
Han W, Li Z, Li Z, Han G, Zhang Z, Yang K, Li X.   +6 more
europepmc   +1 more source

ORBIT‐AMD: Ordinal Risk, Bilateral Imaging, and Trajectory Learning for Age‐Related Macular Degeneration in Multi‐Cohorts

Advanced Science, EarlyView.
Eligibility flow and real‐world AMD burden in the UKB retinal imaging cohort and TMUEH external‐validation cohort. Overview of the ORBIT‐AMD architecture, integrating retinal representation pretraining, bilateral eye‐graph modeling and concept bottleneck learning to support ordered risk, bilateral context, interpretable lesion concepts, longitudinal ...
Xuehao Cui, Dejia Wen, Patrick Yu‐Wai‐Man, Xiaorong Li   +3 more
wiley   +1 more source