Results 191 to 200 of about 126,550 (315)

CXCL10 Regulates Pressure Overload-Induced Heart Failure. [PDF]

JACC Basic Transl Sci
Souza-Neto F, Le P, Abdrabbo M, Alamgir A, Wang H, Ferreira de Araujo N, Mikkila JL, Sanches B, Parthiban P, Moon R, Herman A, Adams AB, Prins KW, Guatimosim S, Schuldt N, Revelo XS, van Berlo JH.   +16 more
europepmc   +1 more source

Sustained Delivery of a Shingles Subunit Vaccine Overcomes Age‐Related Declines in Humoral and Cellular Immunity Relative to Shingrix

Advanced Science, EarlyView.
Sustained delivery of a shingles subunit vaccine from an injectable polymer–nanoparticle hydrogel enhanced the potency, durability, and breadth of immune responses in aged mice while minimizing inflammatory cytokine production and reactogenicity. This strategy decouples immunogenicity from reactogenicity and offers a promising approach to improve ...
Ye Eun Song, Jerry Yan, Ben S. Ou, Olivia M. Saouaf, Noah Eckman, E. A. Appel   +5 more
wiley   +1 more source

Autonomic Dysregulation Attributed to Vertebral Artery Insufficiency Secondary to Subclavian Steal Syndrome: A Case Report. [PDF]

Cureus
Zargarian L, Nguyen H, Sanghera M, Megerdechyan A, Hughes WS.   +4 more
europepmc   +1 more source

Microenvironment‐Responsive Nanomedicine Enables Vertical Modulation of Mitochondrial Pathological Networks in Myocardial Ischemia–Reperfusion Injury

Advanced Science, EarlyView.
A mitochondria‐targeted, microenvironment‐responsive nanoplatform enables pH/ROS‐triggered co‐delivery of berberine and isoliensinine to orchestrate ROS scavenging, inflammation suppression, and apoptosis inhibition. This vertical modulation of mitochondrial pathological networks preserves mitochondrial function and effectively mitigates myocardial ...
Jue Wang, Jia Zhou, Wenqin Yuan, Tianjiao Zhao, Yunying Huang, Yingci Xia, Yuting Lin, Fei Li, Qiong Huang, Chong Liu, Kelong Ai, Qun Qin   +11 more
wiley   +1 more source

Validation of Monocular Pupillometry in Healthy Controls and Patients With Autonomic Dysfunction: Pupillary Biomarkers for Autonomic Failure. [PDF]

Eur J Neurol
Sander L, Oommen G, Brophy C, Bohus-Roper S, Chiaro G, Bremner F, Iodice V.   +6 more
europepmc   +1 more source

144: Pathologic vascular response in fetal-placental arteries constricted with thromboxane after exposure to maternal hyperglycemia in a human dual perfusion placenta model [PDF]

American Journal of Obstetrics and Gynecology, 2016
Luckey C. Reed, Nicholas Leronimakis, Peter G. Napolitano   +2 more
openaire   +1 more source

Ti‐Doping Activates Adjacent Zr Sites in Bimetallic MOFs for Cooperative Phospholipid Removals in Human Biomonitoring

Advanced Science, EarlyView.
Ti‐doped Zr/Ti bimetallic MOFs activate neighboring Zr sites to selectively capture phospholipids from serum through cooperative interactions. In nontargeted screening, the material minimizes matrix interference, expands detectable feature coverage, and enables broad recovery of diverse chemical hazards, providing a powerful cleanup strategy for LC ...
Yanmin Liang, Hongyue Ma, Feier Bai, Jing Zhang, Yan Qi, Bing Shao   +5 more
wiley   +1 more source

Macrophage-Dependent Intercellular Crosstalk in Multiphenotypic Heart Failure With Preserved Ejection Fraction. [PDF]

J Am Heart Assoc
Huang Y, Luo L, Ma X, Huang Y, Zhang C, Hao X, Zhang L, Zhu H, Dai L, Liu M.   +9 more
europepmc   +1 more source

Automation and Active Learning for the Multi‐Objective Optimization of Antibody Formulations

Advanced Science, EarlyView.
Successful antibody formulation necessitates balancing factors such as thermal stability, colloidal stability, and viscosity across a vast excipient design space. This work integrates robotic liquid handling, high‐throughput biophysical characterization, and multi‐objective Bayesian optimization in an iterative closed‐loop Design‐Build‐Test‐Learn cycle.
D. Christopher Radford, Matthew Tamasi, Elena Di Mare, Adam J. Gormley   +3 more
wiley   +1 more source

Characterizing pancreatic cancer-associated fibroblast heterogeneity in vascular microphysiological systems. [PDF]

Angiogenesis
Blackledge CW, Gullion S, McCabe I, Van NNK, Hariharan A, Luan C, Peng XL, Polacheck WJ, Yeh JJ, Shelton SE.   +9 more
europepmc   +1 more source